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循环游离DNA完整性检测的临床应用研究进展 被引量：5

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摘要 循环游离DNA(ccfDNA)是一种新的肿瘤标志物。现普遍认为细胞凋亡产生DNA短片段,长度为185～200 bp;而肿瘤细胞坏死产生的DNA片段,由于不完全消化而呈现长度多样化,以长链DNA片段为主。ccfDNA完整性检测广泛应用于多种肿瘤。DNA完整性一般以DNA长、短片段扩增产物的浓度比值来表示,其对肿瘤早期诊断、肿瘤分期、分级、放疗和化疗疗效监测等有重要意义。本文就ccfDNA完整性检的检测方法及其临床应用作一综述。
作者 郁佳佳 施维 鞠少卿
机构地区 南通大学附属医院医学检验中心 南通大学附属医院外科综合实验室 南通大学公共卫生学院医学检验研究室
出处 《临床检验杂志》 CAS CSCD 北大核心 2013年第2期121-123,共3页 Chinese Journal of Clinical Laboratory Science
基金 国家自然科学基金(81000725) 江苏省卫生厅科技项目(2201017) 南通市社会发展基金(S2010021) 江苏省医学创新团队与领军人才项目(LJ201133)
关键词 循环游离DNA DNA完整性 肿瘤诊断 疗效监测 产前诊断
分类号 R730.43 [医药卫生—肿瘤]
  • 相关文献

参考文献28

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二级参考文献30

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共引文献57

同被引文献28

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引证文献5

二级引证文献15

临床检验杂志
2013年 第2期

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