腹部外科疾病细胞因子水平与Apache Ⅱ评分临床分析

Clinical Analysis on the Relationship between Cytokines Levels and Apache II Score in Patients with Abdominal Surgical Diseases

目的:了解腹部外科疾病患者细胞因子水平与预后的关系。方法:实验同时测定了62例患者血清中肿瘤坏死因子、粒细胞集落刺激因子、可溶性白细胞介素-2受体和C反应蛋白水平。结果:依Apache Ⅱ评分分组,重症组肿瘤坏死因子、可溶性白细胞介素-2受体和C反应蛋白高于轻症组,肿瘤坏死因子与C反应蛋白成正相关。重症组中,死亡组与存活组Apache Ⅱ评分有显著性差异,死亡组肿瘤坏死因子、可溶性白细胞介素-2受体和C反应蛋白高于存活组,肿瘤坏死因子与C反应蛋白成正相关。结论:结果提示机体炎性反应的启动和免疫功能的抑制,可直接影响患者的预后。

Objective:To find out the relationship between prognosis and levels of cytokines in patients with abdominal surgical dis-eases. Methods:To measure the levels of tumor necrosis factor (TNF),granulocytecolony stimulating actor (G-CSF),soluble interleukin-2 receptor (sIL-2R) and C reactive protein (CRP) in the serum of 62 patients. According to Apache ⅡScore, the patients were divided into severe group and mild group. Results:The levels of TNF,sIL-2R and CRP in the severe group were obviously higher than those in the mild group. The concentration of TNF in the serum was positively correlated with CRP. In the severe group,TNF,sIL-2R and CRP of non-survivors were obviously higher than those of survivors, the TNF was correlated with the CRP. Conclusion: The outcome showed that the start-up of inflammation reaction and inhibition of immune system in the patients' body may affect the prognosis directly.