摘要
目的:探讨雌激素受体(ER)、孕激素受体(PR)在卵巢原发性上皮性肿瘤中的临床意义。方法:采用免疫组化法测定67例恶性肿瘤、44例良性肿瘤和10例正常卵巢ER、PR状态。结果:ER、PR阳性率在恶性肿瘤分别为58.2%、26.9%,良性肿瘤分别为36.4%、31.6%,正常卵巢各为40%、70%。恶性肿瘤ER表达明显高于良性肿瘤及正常卵巢(P〈0.05),而PR表达则较低(P〈0.05)。
Objective:To probe the clinical significance of testing estrogen receptor (ER) and progesterone receptor (PR) in pa-tients with ovarian epithelial tumor. Methods:The immunohistochemical detection of ER and PR was performed in 67 cases of malignant tumor,44 cases of benign tumor and 10 cases of normal ovary. Results:The positive rates of ER and PR in ma-lignant tumor,benign tumor and normal ovary were 58.2% and 26.9% ,36.4% and 31.6% ,40.0% and 70.0% respec-tively . The ER expression in malignant tumor was obviously higher than that in benign tumor or normal ovary (P <C 0.05), the PR expression was lower (P < 0.05). Based on multivariate analysis, the PR status was associated with improved surviv-al (P<0.05). The follow-up information suggested that steroid receptors positive status were correlated with a long survival time. Conclusion:The ER and PR status were relevant to prognosis in ovarian epithelial carcinomas.
出处
《天津医药》
CAS
2000年第8期456-468,共13页
Tianjin Medical Journal