新生儿脐血砷、硒水平与新生儿生长指标关系的研究

Research on the relationship between umbilical arsenic,selenium concentrations and neonatal growth indicators

目的:以脐血砷、硒水平为指标,探讨两种元素对于新生儿生长发育的影响。方法:选择在该院出生的足月新生儿213例作为研究对象,采集新生儿脐带血并测定脐血砷和脐血硒。结果:脐血砷水平与新生儿体重及身长的相关性不明显,差异无统计学意义(体重:r=-0.031,P=0.682;身长:r=-0.082,P=0.253)。而脐血砷水平与头围呈正相关,差异有统计学意义(r=0.322,P=0.000),脐血硒水平与体重和身长的相关性不显著,差异无统计学意义(体重:r=0.343,P=0.062;身长:r=0.295,P=0.081)。而脐血硒水平与头围呈负相关,差异有统计学意义(r=-0.413,P=0.000),新生儿头围与脐血砷水平存在正相关(β=0.08,P=0.00),与脐血硒水平的相关性无明显统计学意义(β=-0.03,P=0.31)。结论:新生儿脐血砷水平对于新生儿的生长发育存在负面影响,而微量元素硒则可能能够拮抗这种不良么应。

Objective： To explore the effects of arsenic and selenium in umbilical cord blood on neonatal growth anddevelopment. Methods： A total of 213 full -term neonates in the hospital were selected as study objects. The levels of arsenic and selenium in umbilical cord blood of the neonates were collected and detected. Results： The correlation between the arsenic concentration in umbilical cord blood and neonatal weight and length was not obvious, there was no statistically significant difference （ weight ： y = - 0. 031 , P = 0. 682 ; height ： T = - 0. 082, P = 0. 253） . But the arsenic concentration in umbilical cord blood was positively correlated with head circ＇- umference, there was statistically significant difference （T = 0. 322, P = 0. 000） . The correlation between selenium concentration in umbili- cal cord blood and neonatal weight and length was not obvious, there was no statistically significant difference （weight ： y = 0. 343, P = 0. 062 ; height ： T = 0. 295, P = 0. 081 ） . But the selenium concentration in umbilical cord blood was negatively correlated with head circum- ference, there was statistically significant difference （y ： -0. 413, P = 0. 000） . The neonatal head circumference was positively correlated with arsenic concentration in umbilical cord blood （β = 0. 08, P = 0. 00）, but there was no correlation between neonatal head circumference and seteninm concentration in umbihca[ cord blood （β = - 0. 03, P = 0. 31 ） . Conclusion： The arsenic concentration in umbilical cord blood has negative impact on neonatal growth and development, while selenium might antagonize this side effect.