胎儿颈项透明层厚度在诊断染色体异常中的应用价值

Application value of fetal nuchal translucency thickness in diagnosis of chromosomal abnormality

目的:探讨胎儿颈项透明层(NT)增厚与胎儿染色体异常的关系。方法:2009年2月～2012年1月在舟山市妇幼保健院进行产前检查的312名NT增厚孕妇行胎儿染色体核型分析。结果:312名孕妇NT增厚孕妇中14例胎儿为染色体核型异常,比例为4.49%,并且NT≥3.0 mm对染色体异常的诊断灵敏度为96.45%,特异性为94.45%。结论:NT增厚对染色体异常的早期筛查具有重要意义,NT≥3.0 mm是进行染色体筛查的一个重要的指标。

Objective： To explore the relationship between nuchal translucency thickness （NT） thickening and fetal chromosomal abnormality. Methods： From February 2009 to January 2012, 312 pregnant women with NT thickening who received prenatal examination in the hospital received fetal karyotype analysis. Results： Among 312 pregnant women with NT thickening, 14 fetuses were found with chro- mosomal abnormality, the proportion was 4.49%, and the sensitivity and specificity of NT~〉3.0 mm for diagnosis of chromosomal abnormali- ty was 96. 45% and 94.45% , respectively. Conclusion： NT thickening has important significance for early screening of chromosomal ab- normality, NT ≥ 3.0 mm is an important index for chromosomal screening.