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硝苯地平与苯磺酸氨氯地平治疗原发性高血压的疗效比较 被引量:9

Comparison of Therapeutic Efficacy of Nifedipine and Amlodipine for Primary Hypertension
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摘要 目的:比较硝苯地平与氨氯地平治疗原发性高血压的临床疗效及不良反应。方法:将2010年2月-2012年2月收治的112例原发性高血压患者随机均分为研究组和对照组,其中对照组采用硝苯地平(30mg,qd)治疗,研究组采用氨氯地平(5mg,qd)治疗,比较两组患者治疗的临床疗效及不良反应。结果:两组患者治疗后收缩压和舒张压比较差异均无统计学意义(P>0.05)。研究组患者临床降压总有效率为92.86%,对照组为85.71%,两组比较差异无统计学意义(P>0.05)。治疗后研究组患者的肾功能指标较治疗前明显改善(P<0.05),而对照组无显著改善(P>0.05)。研究组患者的不良反应发生率(5.36%)低于对照组(17.86%),且差异有统计学意义(P<0.05)。结论:硝苯地平与氨氯地平均能显著降压,但氨氯地平除了具有较好的降压效果和依从性,其不良反应发生率也较低。 OBJECTIVE: To compare clinical efficacy and adverse drug reaction of nifedipine and arnlodipine for primary hypertension. METHODS: 112 Primary hypertension patients admitted in our hospital during Feb. 2010--Feb. 2012 were randomized into study group and control group. Control group received therapy of nifedipine(30 mg, qd) while study group received amlodipine (5 mg, qd). Clinical efficacies and adverse drug reactions were compared between 2 kinds of drugs. RESULTS: There was no statistical significance in systolic pressure and diastolic pressure between 2 groups (P〉0.05). Total effective rate of lowering blood pressure was 92.6% in study group and 85.71% in control group, there was no statistical significance in 2 groups (P〉0.05). Renal function index of study group was improved significantly after treatment (P〈0.05), while there was no significant change in control group (P〉0.05). The incidence of ADR in study group (5.36 % ) was significantly lower than in control group (17.86%), there was statistical significance (P〈0.05). CONCLUSION: Nifedipine and amlodipine can lower blood pressure significantly, but the incidence of ADR induced by amlodipine is lower than nifedipine except for sound hypotensive effect and compliance.
作者 傅嬿
出处 《中国药房》 CAS CSCD 2013年第12期1103-1105,共3页 China Pharmacy
关键词 硝苯地平 苯磺酸氨氯地平 原发性高血压 疗效 不良反应 Nifedipine Amlodipine Primary hypertension Therapeutic efficacy Adverse drug reaction
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