失-C-环1α,25-二羟基维生素D_3类似物的研究——I两个含偕二甲基的手性D环合成子的合成

STUDY ON DE-C-RING 1α,25-DIHYDROXYVITAMIN D_3 ANALOGUS—I THE SYNTHESIS OF TWO NOVEL CHIRAL D-RING SYNTHON WITH GEM-DIMETHYL GROUP

目的 :合成含偕二甲基的手性D环合成子。方法 :以 (+) -内向 3 溴莰酮 2为手性源 ,立体控制合成含偕二甲基的手性D环合成子。结果 :所合成的两个手性D环合成子光学纯度高。结论 :(+) 内向 3 溴莰酮

OBJECTIVE:The synthesis of two novel chiral D ring synthons with gem dimethyl.METHODS:The D ring synthon was synthesized starting from(+) 3 endo bromocamphor.RESULTS:The two novel D ring synthons are of high optical purity.CONCLUSION:The (+) 3 endobromocamphor is ideal chiral template for synthesis of D ring synthon with gem dimethyl group.