蒿甲醚缓释片在狗体内的药代动力学

PHARMACOKINETICS OF DELAYED RELEASE ARTEMETHER TABLET IN DOGS

目的 :建立狗血浆中蒿甲醚的含量测定法 ,并进行蒿甲醚缓释片狗体内药代动力学研究。方法 :用 3p87药代动力学程序计算蒿甲醚普通片及缓释片的药代动力学参数。结果 :方法最低检测浓度 0 0 2 μg·ml 1,线性范围0 0 5～ 12 .5 μg·ml 1,r =0 994,方法回收率 10 3 3%。蒿甲醚缓释片的AUC、Tmax、MRT、T1/ 2 与普通片存在显著性差异。结论 :缓释片与普通片比较具有缓效的特征。

OBJECTIVE:Developing a method for assaying artemether in dog plasma,the pharmacokinentics of delayed release artemether tablet in dogs was investigated.METHODS:Pharmacokinetics parameter of artemether tablet was calculated by 3p87 pharmacokinetics procedure.RESULTS:Lowest detectable concentration 0.2 μg·ml 1 ;linear range 0.05～12.5 μg·ml 1 ,r=0.994;method recovery 103.3%;AUC、T max 、MRT、t 1/2 of delayed release artemether tablet had significant difference with conventional tablet(P<0.01).CONCLUSION:Delayed release character of delayed release Artemether tablet was significant.