六氢苯并[a]喹嗪-4-酮类化合物的合成及其钙拮抗活性初探

PRELIMINARY STUDY ON SYNTHESIS AND Ca^(2+) ANTAGONIZING ACTIVITY OF HEXAHYDROBENZO[a]QUINOLIZIN-4-ONE DERIVATIVES

目的 :设计并合成了一系列六氢苯并 [a]喹嗪 4 酮类化合物 ,对其钙拮抗活性作初步研究 ;方法 :用4 5Ca跨膜内流动测定方法研究了目标物对大鼠主动脉电压依赖性钙离子通道 (PDC)Ca2 + 内流的影响 ;结果 :四个化合物对PDC均有显著阻滞作用 ;结论 :初步药理实验显示 。

OBJECTIVE:A series of derivatives of hexahydrobenzo[a]quinolizin 4 one have been designed and synthesized. Four of them have been determined on their inhabitive effect on potential dependent Ca 2+ channels(PDC).METHODS: The four compounds have been studied on Ca 2+ antagonistic effect in rat aorta by using 45 Ca transmembrane influx technique.RESULTS:The four compounds appeared strongly inhabitive effect on PDC.CONCLUSION:Preliminary results showed that all of the four compounds possessed Ca 2+ antagonizing activity.