TERC基因对宫颈高级别病变(≥CINⅡ)诊断价值的Meta分析

Diagnostic Value of TERC Gene on High-Grade Squamous Intraepithelial Lesion of the Cervix: A Meta-Analysis

目的系统评价TERC基因对宫颈高级别病变(≥CINⅡ)的诊断价值。方法计算机检索PubMed、EMbase、e Cochrane Library等数据库,检索时间截至2012年3月31日。按照纳入和排除标准筛选文献、提取资料并根据诊断性试验准确性质量评价工具(QUADAS)评价质量后,采用Meta-Disc 1.4软件进行Meta分析。结果最终纳入12篇文献,共7 894例患者。Meta分析结果显示:TERC基因诊断宫颈高级别病变的合并灵敏度、特异度和诊断比值比分别为0.81[95%CI(0.80,0.82)]、0.83[95%CI(0.82,0.84)]和17.37[95%CI(8.77,34.41)]。结论 TERC基因单独检测宫颈高级别病变的诊断价值中等,可作为临床诊断的一种辅助方法。

Objective To systematically evaluate the diagnostic value of TERC gene on highgrade squamous in traepithelial lesion （HGSIL） of the cervix. Methods Such databases as PubMed, EMbase, and the Cochrane Library were searched by March 31, 2012. According to the inclusion and exclusion criteria, the literature was screened and the data were extracted. The quality was evaluated in accordance with the quality assessment tool for diagnostic accuracy studies （QUADAS） and the metaanalysis was conducted by using MetaDisc 1.4 software. Result A total of 12 studies involving 7 894 cases were included. The results of metaanalysis showed that the sensitivity, specificity and diagnostic odds ratios of TERC gene on HGSIL of cervix were 0.81 （95%CI 0.80 to 0.82）, 0.83 （95%CI 0.82 to 0.84）, 17.37 （95%CI 8.77 to 34.41）, re spectively. Conclusions The diagnostic value of TERC gene were medium in diagnosing HGSIL of the cervix alone, and it can be used as an optional method in clinical diagnosis.