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HPLC法测定速克感冒片中阿司匹林和扑尔敏的含量 被引量:1

Determination of Aspirin and Chlorpheniramine Maleate in Suke Ganmao Tablets by HPLC
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摘要 目的采用高效液相色谱法(HPLC)测定速克感冒片中阿司匹林和扑尔敏的含量,以期为保证制剂质量稳定提供参考。方法采用两种不同的色谱条件,分别测定阿司匹林和扑尔敏的百分含量。结果两组分在测量范围内均呈线性相关性,回收率分别为100.3%和100.0%。结论建立的方法快速准确,测得样品的百分含量较标示量偏低,提示在生产过程中应注意各成分的投料量。 Objective To determine the content of aspirin and chlorpheniramine maleate in Suke Ganmao tablets by HPLC. Methods The quantification of aspirin and chlorpheniramine maleate was detected respectively by two different HPLC conditions. Results There are both good linear relationships within the detection range, and the average recovery is 100.3% and 100.0% respectively. Conclusion The method is accurate, and the quantification was lower than the marked amount, which suggested us pay attention to the amount of the material that administed in process of production.
出处 《中国药物警戒》 2013年第3期151-154,共4页 Chinese Journal of Pharmacovigilance
关键词 高效液相色谱法 阿司匹林 扑尔敏 速克感冒片 HPLC aspirin chlorpheniramine maleate Suke Ganmao tablets
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