NOE和二维NMR技术在倍半萜化学位移归属中的应用(英文)

APPLICATION OF NOE AND 2D NMR SPECTROSCOPY TO THE ASSIGNMENT OF ~1H AND ^(13)C CHEMICAL SHIFTS IN SESQUI-TERPENOIDS

本文用NOE和二维核磁共振技术-COSY,C-H化学位移相关,C-H远程化学位移相关(COLOC),DEPT对二个倍半萜分子的立体化学结构进行了研究,并对其~1H和^(13)C化学位移进行了归属。

The stereochcmical and structural analysis of two sesquiterpenoids was carried out using nuclear magnetic resonance spectroscopy. Several methods, including ~1H -~1H two -dimensional shift correlation spectroscopy, ^(13)C-~1H two-dimensional shift correlation spectroscopy, COLOC (COrrelation spectroscopy via LOng range Coupling), DEPT (Distortionless Enhancement by Polarization Transfer) were used for chemical shift assignment and configurational analysis. Nuclear Overhauser Effect Spectroscopy was used to establish the stereochemistry. This investigation demonstrates the power of two-dimensional NMR techniques and the Nuclear Overhauser Effect (NOE) in the structural determination of natural products.