刺五加水提物的抗急性炎症及免疫增强作用

Anti-inflammatory and immunology-enhancing potent effect of aqueous extract of Acanthopanax senticosus

[目的]观察刺五加水提物(ASE)的抗炎及免疫增强作用。[方法]采用二甲苯导致小鼠耳肿胀实验、蛋清致大鼠足趾肿胀实验观察ASE的抗炎作用,并采用小鼠碳粒廓清实验、二硝基氟苯诱导小鼠迟发型超敏反应实验观察其提高免疫力的作用。[结果]ASE能减轻二甲苯所致的小鼠耳廓肿胀;能减轻蛋清所致大鼠足趾肿胀;能增加小鼠网状内皮系统吞噬指数;能促进二硝基氟苯诱导小鼠迟发型超敏反应。[结论]ASE具有良好的抗急性炎症及免疫增强作用。

[Objective] To investigate the anti-inflammation and immunology-enhancing effect of aqueous extract of Acanthopanax senticosus （ASE）. [Methods] Various inflammato1~~ models, including the auricular edema induced by xylene in mice and the paw edema induced by albumen in rats were used to explore the effect of anti-inflammation of ASE. The carbon clearing test and the delayed hypersensitivity induced by DNFB were used to observe the immunology-enhancing effect of ASE. [Results] ASE had good preventive action against the auricular edema induced by xylene and the paw edema induced by albumen. It could also increase the phagocytic index and promote the delayed hypersensitivity induced by DNFB. [Conclusion] ASE has good acute anti-inflammatory and immunology enhancing effect.