摘要
目的:探讨碱性成纤维细胞生长因子(bFGF)复合珊瑚羟基磷灰石(CHA)及自体红骨髓(ARBM)修复骨节段性骨缺损的作用,为进一步临床应用提供理论依据。方法:实验于2009年5月～2010年4月在北华大学生命科学研究中心完成。取60只家兔制作双侧桡骨干完全缺损1.0cm模型,随机分成A(bFGF/CHA/ARBM)组、B(CHA)组、C(自体骨)组、D(旷置)组,每组15只。于2、4、8、12周进行大体观察,影像学及组织学评估评价各组修复骨缺损的效果。结果:58只兔子进入结果分析,B组及D组各死亡1只。bFGF/CHA/ARBM组影像学及组织学观察优于单纯CHA组,bFGF/CHA/ARBM组与自体骨组12周时组织学评价无统计学差异。结论:bFGF/CHA/ARBM生物复合材料具有较强的成骨能力,可代替自体骨成为新型的人工骨。
Objective：To explore basic fibroblast growth factor （bFGF） composite coral hydroxyapatite （CHA） and autologous red mulberry （ARBM） to repair of joints segment bone defect of the role, for further provide theoretical basis for clinical application. Methods：The experiment finished in may 2009 - April 2010 in the Beihua university life science research center. Take 60 rabbits production double side radial backbone completely defect 1.0 cm model, randomly divided into A （bFGF/CHA/ARBM） group, B （CHA） group, C（autologous bone） group, D （desert buy） group, 15 rabbits in each group. In 2, 4, 8, 12 weeks for gross observation,evaluated the effect of repair bone defect by Imaging and histology. Results： 58 rabbit into the result analysis B and D group of each death one. BFGF/CHA/ARBM group imaging and histological observation group is better than that of pure CHA, histologie evaluation of BFGF/CHA/ARBM group and autologous bone group on 12th weeks was not statistically different. Conclusion： BFGF/CHA/ARBM biological composite material has strong osteogenesisability, can instead of autologous bone, become a new type of artificial bone.
出处
《中国民康医学》
2013年第4期1-3,33,共4页
Medical Journal of Chinese People’s Health
