摘要
目的:探讨首发精神分裂症患者采用阿立哌唑治疗前后认知功能的变化。方法:采用连线检测、简单视觉空间记忆测验(BVMT-R)、WMS-Ⅲ空间广度测验、霍普金斯词语学习检测(HVLT-R)、定步调听觉连续加法测验(PASAT)和威斯康星卡片分类测验(WCST-64)等认知评估工具对阿立哌唑治疗8周前后60例首发精神分裂症患者和62例健康对照者进行神经心理测验。结果:首发精神分裂症患者治疗前的神经心理测验成绩显著差于治疗后和健康对照组(P<0.05);经阿立哌唑治疗8周后达到临床痊愈标准患者的神经心理测验成绩除WMS-Ⅲ空间广度测验外,其他大部分测验成绩仍然显著差于健康对照组(P<0.05)。结论:首发精神分裂症患者存在处理速度、工作记忆、言语记忆、空间记忆、注意警觉和执行功能广泛的认知功能损害,阿立哌唑治疗可以部分改善认知缺陷,但精神症状达到临床痊愈患者仍然存在多个领域认知缺陷,显示认知缺陷是精神分裂症的内表型。
Objective : To explore difference of cognitive function in first - episode schizophrenia patients between before and after Aripiprazole treatment. Methods :Trail Making test, BVMT - R Wechsler Memory Scale - II ( WMS -III ) Spatial span task, HVLT - R, PASAT and WCST - 64 were used to assess 60 first - episode schizophrenia patients before and after eight weeks of Aripiprazole treatment and 62 healthy controls. Results: Compared with control group, first -episode schizophrenia patients before and after Aripiprazole treatment were significantly worse in all neuropsychological test scores ( P 〈 0.05 ). Except for WMS - III spatial span tests, other all neuropsychological test scores in patients after Arlpiprazole treatment and the patients who reached clinical remission were significantly worse than control group ( P 〈 0.05 ). Conclusion: The cognitive function deficits in first - episode schizophrenia patients were affected in wide range, and cognitive impairment were significantly improved by Aripiprazole treatment, but most cognitive function deficits were still showed in patients with remission after the treatment. It indicates the cognitive deficits may be an endopbenotype of schizophrenia.
出处
《中国民康医学》
2013年第4期14-15,共2页
Medical Journal of Chinese People’s Health
关键词
首发精神分裂症
认知功能
阿立哌唑
First - episode schizophrenia
Ccognitive function
Aripiprazole