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阿立哌唑治疗首发精神分裂症前后认知功能比较 被引量:4

Comparison of cognitive function in first-episode schizophrenia patients between before and after Aripiprazole treatment
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摘要 目的:探讨首发精神分裂症患者采用阿立哌唑治疗前后认知功能的变化。方法:采用连线检测、简单视觉空间记忆测验(BVMT-R)、WMS-Ⅲ空间广度测验、霍普金斯词语学习检测(HVLT-R)、定步调听觉连续加法测验(PASAT)和威斯康星卡片分类测验(WCST-64)等认知评估工具对阿立哌唑治疗8周前后60例首发精神分裂症患者和62例健康对照者进行神经心理测验。结果:首发精神分裂症患者治疗前的神经心理测验成绩显著差于治疗后和健康对照组(P<0.05);经阿立哌唑治疗8周后达到临床痊愈标准患者的神经心理测验成绩除WMS-Ⅲ空间广度测验外,其他大部分测验成绩仍然显著差于健康对照组(P<0.05)。结论:首发精神分裂症患者存在处理速度、工作记忆、言语记忆、空间记忆、注意警觉和执行功能广泛的认知功能损害,阿立哌唑治疗可以部分改善认知缺陷,但精神症状达到临床痊愈患者仍然存在多个领域认知缺陷,显示认知缺陷是精神分裂症的内表型。 Objective : To explore difference of cognitive function in first - episode schizophrenia patients between before and after Aripiprazole treatment. Methods :Trail Making test, BVMT - R Wechsler Memory Scale - II ( WMS -III ) Spatial span task, HVLT - R, PASAT and WCST - 64 were used to assess 60 first - episode schizophrenia patients before and after eight weeks of Aripiprazole treatment and 62 healthy controls. Results: Compared with control group, first -episode schizophrenia patients before and after Aripiprazole treatment were significantly worse in all neuropsychological test scores ( P 〈 0.05 ). Except for WMS - III spatial span tests, other all neuropsychological test scores in patients after Arlpiprazole treatment and the patients who reached clinical remission were significantly worse than control group ( P 〈 0.05 ). Conclusion: The cognitive function deficits in first - episode schizophrenia patients were affected in wide range, and cognitive impairment were significantly improved by Aripiprazole treatment, but most cognitive function deficits were still showed in patients with remission after the treatment. It indicates the cognitive deficits may be an endopbenotype of schizophrenia.
出处 《中国民康医学》 2013年第4期14-15,共2页 Medical Journal of Chinese People’s Health
关键词 首发精神分裂症 认知功能 阿立哌唑 First - episode schizophrenia Ccognitive function Aripiprazole
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参考文献4

  • 1Johnson I, Ben AO, Kebir O. Evaluation of correlations between cognitive performances and clinical dimensions of schizophrenia [J~. Tunis Med,2009,87(10) :664 -669.
  • 2Matsui M, Arai H, Yonezawa M, et al. The effects of cognitive reha- bilitation on social knowledge in patients with schizophrenia [ J ]. AppI Neuropsycho1,2009,16 (3) : 158 - 164.
  • 3奈效祯,史丽,宋春联,赵绍锋.阿立哌唑与氯丙嗪对精神分裂症患者认知功能的影响[J].中国实用神经疾病杂志,2009,12(5):13-15. 被引量:10
  • 4Rund BR, Melle 1, Friis S, et al ,The course of neurocognitive func- tioning in first - episode psychosis and its relation to premorbid adjustment, duration of untreated psychosis, and relapse [ J ]. Schlzophr Res ,2007,91 ( 1 - 3 ) : 132 - 140.

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  • 1马小红,王强,孙学礼,李涛,邓伟,蒙华庆,胡峻梅,王英成,刘协和.首发精神分裂症患者神经认知功能的遗传学分析[J].中华精神科杂志,2004,37(3):140-144. 被引量:17
  • 2朱建中,黄寅平,徐清,诸春明,季莉.阿立哌唑治疗注意缺陷与多动障碍对照观察[J].临床精神医学杂志,2006,16(6):348-349. 被引量:3
  • 3舒畅,白雪光,王晓萍,白静.阿立哌唑治疗儿童孤独症与精神发育迟滞临床观察[J].临床精神医学杂志,2007,17(5):333-334. 被引量:14
  • 4Finding RL,RobbA,Nyilas M. A multiple-center,randomized,double-blind placebo-controlled study of oral aripiprazole for treatment of adolescentswith schizophrenia[J].{H}AMERICAN JOURNAL OF PSYCHIATRY,2008,(11):1432.
  • 5Biedennan J,MickE,SpencerT. An open-label trial of aripiprazole monotherapy in children andadolescents with bipolar disorder[J].CNS Spectrum,2007,(09):683.
  • 6Seo WS,Sung H M,Sea HS. Aripiprazole treatmentofchildren and adolescents with Tourette disorder orchronic ticdisorder[J].Journal of Child and Adolescent Psychophannacology,2008,(02):197.
  • 7YooH K,Kim J Y,Kim CY. A pilot study of aripiprazole in children and adolescents witll Tourette'S disorder[J].Journal of Children and adolescent Psyehopharmacx logy,2006,(04):505.
  • 8MirandaCM,Castiglioni TC. Aripiprazole for the treatment ofTourette symdmme.Experience in 10 patients[J].Revista Medicade Chile,2007,(06):773.
  • 9Budman C,Coffey B J,SheehterR. Aripiprazole in children and adolescents with Tourette disorder with and without explosive outbursts[J].{H}Journal of Child And Adolescent Psychopharmacology,2008,(05):509.
  • 10StiglerKA,DienerJ T,KohnAE. Aripiprazole in Pervasive Developmental Disorder Not Otherwise Specified and Asperger'S Diaor-der.A 14-Week,Prospective,open-Label Study[J].{H}Journal of Child And Adolescent Psychopharmacology,2009,(03):265.

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