摘要
细菌耐药日益严重,单一抗菌药物难以完全杀灭耐药菌。应用低频超声技术联合抗菌药物,无论是对于浮游态菌还是生物被膜态菌,都能增强抗菌药物的杀菌或抑菌作用。其机制主要为空化效应。目前,低频超声技术已探索性应用于人体局部感染治疗中。作为一种可靶向治疗的非侵入性疗法,低频超声具有很大的临床应用潜能。此外,低频超声技术在基因转染上具有优势,并可通过改变基因来影响细菌耐药性。
It is difficult to eradicate bacteria completely with single antibiotic because of serious drug resistance. The combination of low-frequency ultrasound technology and antibiotics could enhance the bactericidal or bacteriostatic effect of antibiotics on both planktonic bacteria and bacterial biofilm. The primary mechanism may be cavitation effect. Currently, low- frequency ultrasound technology has been applied to local infection treatment. As a non-invasive and targeted therapy, low-frequency ultrasound technology has great potential use in clinic. In addition, the low-frequency ultrasound technology has advantage on gene transfection and inhibition of bacterial resistance by changing the genes.
出处
《中国药物应用与监测》
CAS
2013年第1期55-58,共4页
Chinese Journal of Drug Application and Monitoring
关键词
低频超声
浮游态菌
生物被膜
慢性创伤
植入假体
基因转染
空化效应
Low-frequency ultrasound
Planktonic bacteria
Bacterial biofilm
Chronic wound
Implant
Gene transfection
Cavitation effect
