脑钠肽在COPD合并肺心病急性发作中的研究

Study on Brain Natriuretic Peptide in AECOPD and Chronic Cor Pulmonale Patients

目的:探讨血脑钠肽水平在肺源性心脏病患者急性发作时及治疗后2周的变化并分析其临床意义。方法:75例COPD合并肺心病急性发作期患者在常规治疗前、后检测血中BNP及CRP水平及动脉血氧分压、二氧化碳分压。结果:治疗前的BNP及CRP水平均显著高于治疗后(P<0.01),治疗后PaO2较治疗前显著上升(P<0.05)。结论:COPD合并肺心病急性发作期患者血中BNP及CRP水平明显增高,可以作为急性发作及好转的指标。

Objective：To evaluate the level of BNP in patients with chronic obstructive pulmonary disease（COPD） and chronic cor pulmonale.Methods：Before and after 14 days therapy,plasma BNP levels and blood gas analysis were detected in 75 patients with COPD and chronic cor pulmonale.Results：The serum BNP,CRP level before therapy were significantly higher than that of afer therapy（P＆lt;0.01）.After therapy,the PaCO2 level were significantly lower than pre-treatment（P＆lt;0.01）,the PaO2 after therapy were significantly higher than pre-treatment（P＆lt;0.05）.Conclusion：BNP and the CRP level in patients with acute COPD and chronic cor pulmonale were significantly higher.BNP and CRP level could be used as AECOPD and recovery index.