复方米非司酮对人早孕蜕膜组织雌孕激素受体的影响

The Effect of Mifepristone Compound on Esrtrogen and Progestrone Receptors of Early Pregnancy in Decidua

观察服用复方米非司酮片 (米非司酮 + AF-5 3)后早孕妇女蜕膜组织雌孕激素受体的变化。 6 0名孕 6～ 7周的妇女被随机分为 6组 ,A组 :对照组 ;B组 :米非司酮 40 mg/次 ;C组 :米非司酮 75 mg/次 ;D组 :复方米非司酮 1片 (米非司酮 2 0 mg+ AF-5 35 mg) ;E组 :复方米非司酮 1片 (米非司酮 30 mg+ AF-5 35 mg) ;F组 :复方米非司酮 1片 (米非司酮40 mg+ AF-5 35 mg)。以上各服药组 ,均为上述剂量每日 1次 ,连服 2日。服药 48h后手术终止妊娠 ,取蜕膜组织 ,放射性配体结合试验测定其胞浆、胞核雌、孕激素受体浓度。结果显示 :复方米非司酮各配伍组均显著降低孕激素受体 (PR) ,升高雌激素受体 (ER) ,改变 ER/PR,促进流产发生。 E组使胞浆雌激素受体 (Ec R)显著高于其它各用药组 ,可能有利于流产后雌激素尽快作用于 ER,促进内膜恢复。结论提示复方米非司酮中米非司酮与AF-5 3配伍具有协同作用 ,改变了雌孕激素受体比例 ,促进流产的发生 。

WT5BZ] The effect of mifepristone compound on estrogen and progesterone receptors in decidua was studied. Sixty normal early pregnant volunteers(≤49 d)were randomly allocated into 6 groups,10 in each group. Group A:control group; Group B and Group C were administrated mifepristone 40 mg and 75 mg orally respectively, once per day, for two days; Group D(Group 4∶1): given mifepristone compound 1 tablet orally (mifepristone 20 mg+AF 53 5 mg)a day, for two days; Group E(Group 6∶1): given mifepristone compound 1 tablet(mifepristone 30 mg + AF 53 5 mg)a day, for two days; Group F(Group 8∶1): mifepristone compound 1 tablet(mifepristone 40 mg + AF 53 5 mg), at the same closeage above; concentration of ER and PR was measured by radio ligand assay in decidua tissue which were obstained after 48 h when mifepristone or mifepristone compound was administrated. Mifepristone compound in different doses significantly decreased the content of PR and increased ER and changed the balance of ER/PR. Among groups of mifepristone compound, Group E could also increased the concentration of EcR, which might be in favour of the endometrium recovery and shorten the bleeding days after abortion.