苦参生物成碱的二维核磁共振谱(2D—NMR)研究——Ⅰ.中国东北产苦参中的N-甲基金雀儿碱与氧化槐根碱的2D—NMR研究(英文)

STUDIES ON THE ALKALOIDS OF SOPHORA FLAVESCENS BY 2D - NMR——Ⅰ. The Main Alkaloids of Sophora flavescens Ait. From Northeast China and 2D-NMR of N - methylcytisine and Oxysophocarpine

由我国东北产的苦参中分离出七种生物碱。由MS、IR及2D-NMR鉴定为:(+)-苦参碱、(+)-氧化苦参碱、5α-羟基苦参碱、N-甲基金雀儿碱、9α-羟基苦参碱及氧化槐根碱。另一个生物碱(6)的化学结构尚在鉴定之中。本课题采用了二种2D-NMR技术,H-H相关谱(300、400及500MHz)及C-H相关谱(H:300MHz;C:75MHz)。先发表其中两个生物碱的2D-NMR,其它将陆续发表。

Seven alkaloids have been isolated from Sophora flavescens Ait, which has its origin in Northeast China. Six of these alkaloids have been positively identified by MS, IR and 2D-NMR. These are (+) -matrine (1), (+) -oxymatrine (2), (+) -5α-hydroxymatrine (3), (-) -N- methylcytisine (4), ( +) - 9α-hydroxymatrine (5), and ( +) -oxysophocarpine (7). The structure of the other alkaloid (6) is currently being determined. Two types of 2D-NMR H-H COSY ( 500MHz, 400MHz or 300MHz)and C-H COSY (C: 75MHz, H: 300MHz) techniques have been used.