氟比洛芬酯和氯诺昔康对踝关节微骨折术超前镇痛的比较研究

Study on Preemptive Analgesic Effect of Flurbiprofen Axetil and Lornoxicam During Ankle Microfracture Under Local Anesthesia

目的比较氟比洛芬酯、氯诺昔康用于局麻踝关节微骨折术超前镇痛的疗效。方法收集2009年9月～2011年8月于解放军总医院骨科收治的踝关节距骨软骨损伤患者的临床资料,随机分为3组,氟比洛芬酯组、氯诺昔康组和对照组。分别于术中和术后观察疼痛视觉模拟评分(VAS)。结果关节镜清理时3组之间的VAS差别无显著性意义(P>0.05);微骨折术时氟比洛芬酯组和氯诺昔康组的评分低于对照组,其差别有显著性意义(P<0.05),而氟比洛芬酯组和氯诺昔康组之间的VAS差别无显著性意义(P>0.05)。术后1 h、4 h被动屈伸踝关节VAS氟比洛芬酯组<氯诺昔康组<对照组,其差别有显著性意义(P<0.05)。结论在局麻踝关节微骨折术的超前镇痛中,氟比洛芬酯、氯诺昔康均能达到满意的术中镇痛效果,而氟比洛芬酯术后镇痛效果更为显著。

Objective To observe the preemptive analgesic effect of flurbiprofen axetil and lomoxicam during ankle microfracture under local anesthesia. Methods Sixty patients who had undergone ankle microfracture under local anesthesia were divided into three groups according to different analgesics：flurbiprofen axetil group, lomoxicam group and control group. Analgesic efficacy was assessed by visual analoge scales （VAS） during and after surgery. Results There was no significant difference between VAS scoring of the three groups druing arthroscopic debridement. The VAS score of flurbiprofen axetil group and lomoxicam group was significantly lower than that of control group. There was no significant difference between flurbiprofen axetil group and lomoxicam group. The VAS score of lornoxicam group was sig- nificantly higher than that of flurbiprofen axetil group but significantly lower than that of control group 1 h and 4 h after surgery. Conclusion Flubiprofen axetil and lomoxicam can produce preemptive analgesic effect during ankle microfracture under local anesthesia. Flubiprofen axetil has better effect than lomoxicam after surgery.