甘肃省某高校2008至2010年新生体检血清ALT检测结果及影响因素分析

Analysis on serum ALT detection results and influence factors in the fresh students from some universities of Gansu province 2008-2010 year

目的了解近3年来甘肃省某高校新生丙氨酸氨基转移酶(ALT)异常情况及相关影响因素,探讨大学生肝炎的防治措施。方法对甘肃省某高校2008年至2010年6 852名入校新生进行健康体检,分析血清ALT水平及引起ALT异常的因素。结果 6 852名新生中ALT阳性率为2.30%,男、女生之间差异无统计学意义(P>0.05);乙型肝炎表面抗原(HBsAg)阳性率为3.40%,男、女生之间差异有统计学意义(P<0.05);ALT异常的因素中HBsAg阳性比例最高(19.74%),其次为脂肪肝(18.47%),第三为疲劳(17.83%)。男生的脂肪肝患病率稍高于女生,但差异无统计学意义(P>0.05);女生的疲劳率高于男生(P<0.05)。多因素非条件Logistic回归分析显示,感染其他病毒、脂肪肝、疲劳、家族遗传史、口服营养品、服用其他药物是影响ALT异常的因素。结论甘肃省某高校新生HBsAg阳性率低于全国同年龄组。对于ALT异常的学生可通过改变生活习惯与药物治疗相结合的综合方法进行治疗。

Objective To study the abnormality and influence factors of alanine aminotransferase（ALT） in the fresh students from some universities of Gansu province 2008-2010 year,and to investigate the prevention from hepatitis in universities. Methods A total of 6 852 fresh students were enrolled for physical examination in some universities of Gansu province 2008-2010 year. The serum ALT levels and influence factors were analyzed. Results The positive rate of ALT in 6 852 fresh students was 2.30%,and there was no statistical significance between male and female students（P〉0.05）. The positive rate of hepatitis surface antigen（HBsAg） was 3.40%,and there were statistical significances between male and female students（P〈0.05）. Among the influence factors for ALT abnormality,the positivity of HBsAg was the highest,accounted for 19.74%,and fatty liver（18.47%） and tiredness（17.83%）. The number of males with fatty liver was more than that of females slightly with no statistical significance（P〉0.05）,however,tiredness in females accounted markedly higher than that in males（P〈0.05）. The results of multivariate unconditioned Logistic regression analysis showed that the influence factors for ALT abnormality included virus infection,fatty liver,tiredness,family genetic history,oral nutriments and taking other medicines. Conclusions The positive rate of HBsAg in fresh students from some universities of Gansu province is lower than that of other same aged population through whole country. The students with ALT abnormality could be cured by changing living habits combined with medicine treatment.