确山县HIV单阳家庭HCV及梅毒螺旋体感染情况调查

The infection of hepatitis C virus and treponema pallidum among HIV single-infection couples in Queshan county

目的了解确山县人类免疫缺陷病毒(HIV)单阳家庭感染丙型肝炎病毒(HCV)及梅毒螺旋体的情况。方法以确山县362户HIV单阳家庭夫妻双方为实验组,完成HIV阳性配偶采样169例,完成HIV阴性配偶采样339例。采用酶联免疫吸附试验(ELISA)检测血清中HCV抗体及梅毒螺旋体抗体。以确山县本地医院同期进行健康体检者1 700名作为正常对照。结果单阳家庭169例HIV阳性者HCV抗体阳性145例,阳性率85.8%,明显高于HIV阴性者HCV抗体阳性率[34.8%(118/339),χ2=117.4,P<0.01];以上2组人群HCV感染率均较正常对照组[4.6%(78/1 700)]明显升高(χ2=891.3,P<0.01)。以家庭为单位,单阳家庭HCV感染率为91.1%。单阳家庭夫妻双方梅毒螺旋体感染率与正常对照组比较,差异无统计学意义(χ2=1.764,P>0.05)。结论确山县HIV单阳家庭HIV的传播途径仍以血液途径为主,在预防HIV传播的同时应注意预防HCV的合并感染。

Objective To understand the infection of hepatitis C virus（HCV） and treponema pallidum among human immunodeficiency virus（HIV） single-infection couples in Queshan county. Methods A total of 362 HIV single-infection couples in Queshan county were enrolled as experiment group. The blood of 169 HIV-positive spouses and 339 HIV-negative spouses had been extracted. The anti-HCV and anti-treponema pallidum antibodies had been detected by enzyme-linked immunosorbent assay（ELISA）. The 1 700 healthy subjects in local hospital were enrolled as healthy controls. Results The HCV infection rate of the HIV-positive spouses was 85.8%（145/169）.It was significantly higher than that of HIV-negative spouses[34.8%（118/339）,χ2=117.4,P〈0.01]. The HCV infection rates of the 2 groups were higher than that of control group [4.6%（78/1 700）,χ2=891.3,P〈0.01]. The HCV infection rate of HIV single-infection couples was 91.1%. The difference of treponema pallidum incidence was not significant between experiment group and control group（χ2=1.764,P〉0.05）. Conclusions It is indicated that blood is the main route of HIV infection among HIV single-infection couples in Queshan county,and the HCV concurrent infection should be paid attention while preventing the pathophoresis of HCV.