吸烟和碘缺乏对生育期女性抗氧化功能影响

The Effect of Smoke Inhalation and Iodine Deficiency to Child bearing Womens′ Antioxidation Action

采用 2× 2析因实验设计 ,对缺碘 (ID)及吸烟 (SI)的2 0～ 40岁女性抗氧化功能水平进行观察 ,结果发现 :ID和SI双因素协同作用可使全血GSH Px活性 (85 1± 13 38u/min .pro)和红血球SOD活性 (2 199 4± 174 0 2nu/mg .pro)减弱 ,血清LPO5 35± 1 44nmol/ml)增高和甲状腺体积增大 (P均 <0 0 1) ;未见SI因素对甲状腺体积和ID因素对LPO含量及尿碘、甲状腺体积增大有影响。提示 :缺碘者吸烟可加重甲状腺肿大 ,缺碘还可加重甲状腺过氧化功能的损伤。

This paper adopted 2×2 factor factorial design principle to study the antioxidation ability of the women with iodine deficiency(ID) and smoke inhalation(SI) aged from 20 to 40.The results showed that the joint action effects of ID and SI made glutathione peroxydase(GSH Px) activities(85 1±13 38u/min.pro) and superoxide disputes activities(2199 4±174 02nu/mg.pro)were decreased,serum lipid peroxide(LPO) contents(5 35±1 44nmol/ml) and thyroid's volum were increased (P av <0 01);SI factor's effect to thyroid's volume and ID factor's effect on the increasing of LPO contents,urinary iodine and thyroid's volume didn't show.It was postulated that smoke inhalation can effect smokers',and enhance thyroid's peroxidate injury,it was more important to forbid people from smoking in iodine dificiency areas.