四联疗法根治幽门螺旋杆菌疗效观察

Clinical Observation on Quadruple Therapy for Eradication of Helicobacter Pylori Infection

目的探讨以四联疗法作为一线方案治疗幽门螺旋杆菌(HP)阳性的胃病患者临床疗效,并与传统三联疗法比较,找出更有效的根治HP的办法。方法将105例HP阳性患者随机分为2组,对照组48例患者给予传统三联疗法,而治疗组57例患者给予含铋剂的四联疗法,治疗结束后4周复查2组患者的HP感染。结果对照组HP根治率为77.08%,治疗组为92.98%,两组结果经统计学检验有显著性差异(P<0.05)。两组的副反应无显著性差异(P>0.05)。结论四联疗法根治幽门螺杆菌感染较三联疗法疗效更显著,且副作用小,费用合理,可作为初治方案进一步推广。

Objective To investigate to observe the clinical efficacy of quadruple therapy as first-line scheme in the treatment of Helicobacter pylori-positive patients with gastric diseases,compare with traditional triple therapy,and find out more effective methods for eradicating HP.Methods 105 cases with HP infectionin in our hospital is randomly divided into two groups.The control group received the traditional triple therapy.The treatment group received the quadruple therapy with bismuth.Four weeksafter the treatment ended,the patients in two groups were reexamined the HP infection.Results The rate of the eradication of HP in control group was 77.08%.The rate of the eradication of HP in treatment group was 92.98%.There were statistically significant differences in the results of two groups（P0.05）.There was no signficant differences in side effect between two groups（P0.05）.Conclusion The clinial effcts of the quadruple therapy for eradication of HP infection are significanly better than the tripe therapy.It has less side effeect,with reasonable cost.It can be used as the initial treatment of HP infection for the clinical popularization.