Barrett′s食管的肠上皮化生研究

A study on intestinal metaplasia in Barrett′s esophagus

目的 探讨影响Barrett′s食管 (Barrett′sesophagus,BE)粘膜中肠上皮化生 (intestinalmeta plasia ,IM)发生的因素。 方法 应用胃镜下和组织学染色方法诊断IM ,并比较 36例存在IM的BE患者与 11例不伴有IM的BE患者在年龄、胃镜下表现及食管运动功能方面的特点。结果 BE患者的年龄、胃镜下BE粘膜的长度及形态 ,均与IM的发生率有关 (P <0 .0 5 ) ;但食管炎的程度及食管运动功能与IM的发生率无关 (P >0 .0 5 )。结论 年龄在 30岁以上、胃镜下舌型BE及长度 3.5cm以上与IM的发生率增加 ,可作为判断BE预后及筛选随访的临床参考指标 ;

Objective The aim of this study was to investigate the factors predisposing to the developmet of intestinal metaplasia (IM) in Barrett′s esophagus (BE). Methods 47 patients of BE were studied. Using endoscopical histological stainning method, 36 patients with IM and 11 patients without IM were compared with age, endoscopic appearance and motility. Results Age and endoscopic features but not esophageal motor function, grades of macroscopic esophagitis were risk factors for the development of IM. Conclusion Age and endoscopic features of BE mucosa are in association with IM and may be the prognostic factors of BE.