脂质过氧化和氧自由基酶活性变化与强迫症临床症状的关系研究

The Relation between Lipid Peroxidation and Clinical Symptom of Obsessive-Compulsive Disorder

目的 :探讨强迫症患者体内氧化、抗氧化系统的状态及其与临床症状的关系。方法 :采用超氧化物歧化酶超微量快速测定法、DTNB直接法、改良红细胞还原型谷胱甘肽二硫双硝基苯甲酸定量测定法和TBA法。测 30例强迫症患者 ,30例正常对照血中SOD、GSH -PX活性 ,GSH含量和血清中LPO含量并做SAS、SDS、Y -BOCS评分。结果 :强迫症组LPO含量 ,SOD活性明显高于正常组、GSH含量则显著降低 (p <0 .0 5 )。强迫症组SAS与SOD呈显著直线正相关。多元逐步回归分析 ,以SAS为应变量显示SAS只与SOD相关。结论 :强迫症患者体内可能存在脂质过氧化亢进 。

Objective: To explore the relation between lipid peroxidation and clinical symptom of obsessive-compulsive disorder (OCD). Method: The contents of blood SOD, GSH-PX, GSH, and LPO of 30 patients with OCD and 30 normal control were measured by means of SOD superminor rapid assay; DTNB and TBA. Clinical assessment was done by clinician with SAS, SDS and Y-BOCS. Result: The activity of SOD, the contents of LPO of patients with OCD were higher significantly (p<0.05) than those of normal control. While the content of blood GSH was higher in patient group (p<0.05). The score of SAS was positively correlated with activity of SOD in patient group (r=0.55, p<0.01). Multiple regression displayed that the score of SAS related only with SOD in patient group. Conclusion: Free radical, lipid peroxidation relate with severity of anxiety symptom of OCD.