期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

链脲佐菌素诱导的大鼠海马神经元超微结构变化 被引量：1

Streptozcin-induced ultrastructual changes in hippocampal neurons of rats
下载PDF
导出
摘要 目的探讨与糖尿病相关的老年性痴呆(Alzheimer’s disease,AD)急性动物模型脑内超微结构变化。方法利用糖尿病模型的诱导药物链脲佐菌素(streptozcin,STZ),通过其侧脑室注射也同样能够诱导大鼠AD样病理变化。并研究通过投射电子显微镜(transmission electronic microscope,TEM)观察STZ侧脑室注射后大鼠海马神经元超微病理学改变。结果STZ的急性侧脑室注射诱导了大鼠海马神经元一系列的超微结构变化,其中包括细胞核变化、内质网异常等,并且发现了突触囊泡和核蛋白体的异常聚集。结论 STZ侧脑室注射诱导的大鼠神经元超微结构异常证实了糖尿病与AD之间特殊的病例关系,为将AD作为一种脑内代谢性疾病进行防治提供了一定的实验室基础。 Objective To explore the ultrastructure changes of Alzheimer＇s disease（AD） animal model relative with diabetes.Methods STZ was used to induce the AD model in rats though intracerebroventricular injection（ICV）.And the ultrastructure changes of the neurons in hippocampus of the rats were observed.Results The short-term ICV of STZ induced a series of ultrastructure changes of the neurons in the hippocampus of rats including alternative nuclear structure,endoplasmic reticulum（ER） abnormality etc.Besides,the abnormalities of synaptic vesicles and ribosomes were observed.Conclusion The alternations of the ultrastructure changes induced by ICV of STZ prove the unique relationship between AD and diabetes,which provides a foundation for making an anti-diabetic agent as a novel therapeutic drug to AD.
作者 姜远红 高充
机构地区 山西医科大学细胞生理学省部共建教育部重点实验室 山西医科大学基础医学院老年医学研究所
出处 《山西医科大学学报》 CAS 2013年第3期178-180,246,247,共5页 Journal of Shanxi Medical University
关键词 老年性痴呆 链脲佐菌素 透射电子显微镜 超微结构 Alzheimer＇s disease streptozcin transmission electron microscope ultrastructre
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献12

  • 1Li L, Holscher C. Common pathological processes in Alzheimer disease and type 2 diabetes : a review[ J ]. Brain Res Rev,2007, 56:384 - 402.
  • 2Brands AM, Kessels RP, de Haan EH, et al. Cerebral dysfunction in type 1 diabetes: effects of insulin, vascular risk factors and blood-glucose levels[ J]. Eur J Pharmacol,2004,490 : 159 - 168.
  • 3Gao C, Holscher C, Liu Y,et al. GSK3 : a key target for the devel- opment of novel treatments for type 2 diabetes mellitus and Alzhe- imer disease[ J]. Rev Neurosci ,2012,23 : 1 - 11.
  • 4Goyal BR, Parmar K, Goyal RK, et al. Beneficial role of telmisar- tan on cardiovascular complications associated with STZ-induced type 2 diabetes in rats [ J ]. Pharmacol Rep,2011,63 :956 - 966.
  • 5Plaschke K, Muller D, Hoyer S. Insulin-resistant brain state (IRBS) changes membrane eomposition of fatty acids in temporal and entorhinal brain cortices of rats : relevance to sporadic Alzhei- mer's disease[ J]? J Neural Transm,2010,117:1419 -1422.
  • 6Li L, Zhang ZF, Holscher C ,et al. (Val (8)) glucagon-like pep- tide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by strepto- zotocin in rat brains[ J]. Eur J Pharmacol,2012 ,674 :280 - 286.
  • 7Cai Z,Zhao Y, Yao S,et al. Increases in beta-amyloid protein in the hippocampus caused by diabetic metabolic disorder are blocked by minocycline through inhibition of NF-kappaB pathway activation[ J]. Pharmacol Rep,2011,63 :381 -391.
  • 8Shonesy BC,Thiruchelvam K, Parameshwaran K,et al. Central in- sulin resistance and synaptic dysfunction in intracerebroventricu- lar-streptozotocin injected rodents. Neurobiol Aging,2012,33:430 e435 -418.
  • 9Hou Y, Zhou L, Yang QD, et al. Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride [ J ]. Neuro- science ,2012,200 : 120 - 129.
  • 10Mikadze E, Mamatsashvili T. Early contact stage of apoptosis : its morphological features and function [ J ]. Sci World J, 2006,6 : 1783 - 1804.

同被引文献36

  • 1邢伟,王彪,许金华,李晓枫,聂海祺,张玉霞,时利德.慢性染铝大鼠海马PKC、MAPK活力与LTP的相关性[J].毒理学杂志,2007,21(2):102-104. 被引量：9
  • 2Li N, Zhang L, Du W, et al. Prevalence of dementia-associated disability among chinese older adults: results from a national sample survey[ J ]. Am J Gefiatr Psychiatry, 2015,23 (3) : 320- 325.
  • 3Foster TC. Involvement of hippocampal synaptic plasticity in age- related memory decline [ J ]. Brain Res Brain Res Rev, 1999, 30 (3) : 236-249.
  • 4Trudeau F, Gagnon S, Massicotte G. Hippocampal synaptic plas- ticity and glutamate receptor regulation: influences of diabetes mellitus[ J]. Eur J Pharmacol, 2004, 490(1-3) : 177-186.
  • 5Howland JG, Wang YT. Synaptic plasticity in learning and mem- ory: stress effects in the hippocampus [ J ]. Prog Brain Res, 2008, 169(2): 145-158.
  • 6Magarinos AM, McEwen BS. Experimental diabetes in rats cau- ses hippocampal dendritic and synaptic reorganization and in- creased glucocorticoid reactivity to stress[ J]. Proc Natl Acad Sci USA, 2000, 97(20) : 11056-11061.
  • 7Dorrell MI, Aguilar E, Friedlander M. Retinal vascular develop- ment is mediated by endothelial filopodia, a preexisting astrocytic template and specific R-cadherin adhesion [ J ]. Invest Ophthal- tool Vis Sci, 2002, 43(11): 3500-3510.
  • 8Wong TY, Klein R, Sharrett AR, et al. Retinal microvascular abnormalities and cognitive impairment in middle-aged per'~ns: the Atherosclerosis Risk in Communities Study [ J ]. Stroke, 2002, 33(6) : 1487-1492.
  • 9Chen YJ, Tsai RK, Wu WC, et aL Enhanced PKCdelta and ERK signaling mediate cell migration of retinal pigment epithelial cells synergistically induced by HGF and EGF [ J ]. PLoS One, 2012, 7(9) : e44937.
  • 10Williams B, Gallacher B, Patel H, et al. Glucose-induced pro- tein kinase C activation regulates vascular permeability factor mR- NA expression and peptide production by human vascular smooth muscle cells in vitro[ J]. Diabetes, 1997, 46 (9) : 1497-1503.

引证文献1

二级引证文献2

山西医科大学学报
2013年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部