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慢性阻塞性肺疾病稳定期患者外周血Th17与Treg细胞表达及意义 被引量：4

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摘要 目的探讨外周血中Th17与Treg细胞表达在慢性阻塞性肺疾病(COPD)发生、发展中的作用。方法研究对象为18例健康不吸烟者(A组)、27例健康吸烟者(B组)及44例COPD患者(C组)。采用流式细胞术检测三组外周血单个核细胞(PBMC)中Th17与Treg细胞百分比,ELISA法检测血浆及PBMC刺激培养液中IL-17水平。结果外周血Th17细胞、Treg细胞、IL-17及培养液中IL-17水平B、C组均高于A组(P<0.01);C组高于B组(P<0.01);C组血浆及PBMC刺激培养液中IL-17水平与第一秒钟用力呼气容积(FEV1)/预计值呈负相关,外周血Th17细胞百分比与FEV1/预计值无相关性,外周血及PBMC刺激培养液中IL-17水平与FEV1/预计值均呈负相关;B组外周血Th17与Treg细胞与吸烟年数均呈正相关;C组外周血Th17细胞与吸烟年数呈正相关,Treg细胞与吸烟年数无相关性。结论 Th17、Treg细胞及IL-17在B、C组外周血表达增加,A组外周血Th17、Treg细胞水平与吸烟年数相关;C组外周血Th17细胞亦与吸烟年数有关,与FEV1/预计值无相关性,IL-17与FEV1/预计值呈负相关。
作者 石建邦 刘辉 严青 夏淮玲 徐晓玲
机构地区 宣城市人民医院 安徽省立医院
出处 《山东医药》 CAS 2013年第6期45-47,共3页 Shandong Medical Journal
关键词 辅助性T细胞17 调节性T细胞 白介素-17 慢性阻塞性肺疾病 吸烟
分类号 R563 [医药卫生—呼吸系统]
  • 相关文献

参考文献14

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共引文献24

同被引文献51

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引证文献4

二级引证文献38

山东医药
2013年 第6期

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