山东招远农村地区原发性高尿酸血症随访调查结果分析

Analysis of a follow-up survey on residents with primary hyperuricemia in the rural areas of Zhaoyuan in Shandong porvince

目的分析沿海地区农村居民原发性高尿酸血症(HUA)的患病情况。方法采用现场调查与入户登记相结合的方式,对山东招远农村地区10个自然村20岁以上的居民(3 744人)血尿酸水平进行检测。根据年龄、性别统计HUA的患病情况,比较HUA患者(HUA组)及血尿酸水平正常者(正常组)一般资料(年龄、收缩压、舒张压等)及血生化指标(血糖、甘油三酯、总胆固醇、尿素氮、血肌酐、血尿酸),Logistic回归分析HUA的危险因素。比较本次调查结果与2009年调查结果的差异。结果与2009年比较,2012年人群整体及HUA组血尿酸水平明显升高(P<0.05)。2012年原发性HUA患病率为19.20%,较2009年增加2.21%,其中男性与女性患病率分别增加2.66%、2.99%(P<0.05)。2012年男性人群以20～29岁年龄段HUA患病率最高,50～59岁年龄段最低;女性人群20～29岁年龄组患病率明显升高,80～89岁年龄段患病率最高。结论山东招远农村地区人群整体血尿酸水平、HUA患病率均呈增高趋势,且趋于年轻化;以女性增加显著。

Objective To analyze the prevalence of hyperuricemia （HUA） among the residents aged≥20 years in the coastal areas in Zhaoyuan, Shandong province and to compare with the result of 2009 survey. Methods A field survey and a registration were conducted. A total of 3 744 inhabitants in 10 natural villages were investigated for the levels of blood uric acid. According to the age and gender, we added up the prevalence of hyperuricemia （HUA） of the local residents, and then compared the general information （ including age, systolic blood pressure, diastolic blood pressure） and blood bio- chemical parameters （including blood glucose, triglycerides, total cholesterol, blood urea nitrogen, serum creatinine, uric acid） between the patients with HUA （HUA group） and the healthy people（ normal group）. The risky factors were ana- lyzed by method of Logistic regression. We also analyzed the differences between the results of the year 2009 and 2012. Results Compared with 2009, the statistical results of 2012 showed that the levels of serum uric acid of all inhabitants and HUA group increased （ P 〈 0.05）. The prevalence of primary HUA was 19.20% in the year of 2012, which was increased by 2.21% than that of 2009. The prevalence of HUA in males and females in 2012 increased by 2.66 % , 2.99% , re- spectively （P 〈 0.05 ）. In the year of 2012, the prevalence of HUA among males aged ≤30 years was the highest ,whereas prevalence aged from 50 to 59 years was the lowest. The prevalence of HUA among females aged≤30 years increased and the highest prevalence was aged from 80 to 89 in female. Conclusion The level of serum uric acid and the prevalence of HUA show an increasing and younger tendency in residents especially in females of Zhaoyuan, Shandong province.