大肠肿瘤患者粪胆汁酸代谢的特点

The metabolism feature of fecal bile acids in patients with colorectal cancer

目的 了解大肠癌患者粪胆汁酸代谢状况 ,探讨粪胆汁酸与大肠癌发生的关联性。方法 应用薄层层析色谱法测定大肠癌患者及正常对照人群粪中胆酸 ,鹅脱氧胆酸 ,脱氧胆酸 ,石胆酸的浓度。结果 大肠癌患者粪总胆汁酸及次级胆汗酸 (脱氧胆酸 ,石胆酸 )浓度以及次级胆汁酸 /初级胆汁酸、脱氧胆酸 /胆酸、石胆酸 /脱氧胆酸等指标明显高于正常对照组。而初级胆汁酸 (胆酸 ,鹅脱氧胆酸 )两组间无统计学差异。结论 粪胆汁酸浓度尤其是次级胆汁酸浓度增高可能是大肠癌促发因素之一。

Objective To evaluate the roles of fecal bile acids in the carcinogenesis of colorectal cancer Methods The concentration of total fecal bile acid (TFBA),cholic acid(CA) , chenodeoxycholic acid(CDCA) ,deoxycholic acid(DCA),Lithocholic acid(LCA)in 24 cases of colorectal cancer patients and 16 cases of control peoples were measured by thin-layer chromatography Results The concentration(mg/g dry feces) of TFBA,DCA,LCA in colorectal cancer patients were significantly higher than that in control group,which were(6 91±0 60)vs(4 36±0 38),(1 61±0 17) vs(0 64±0 06),(2 18±0 25)vs(0 81±0 06)respectively as compare to the control group,the ratio of SBA/PBA,DCA/CA,LCA/DCA were high in colorectal cancer group as well Conclusion The increase of TFBA,especially seccondly bile acid concentration may be one of the etiologic factors of colorectal cancer