激素性青光眼与糖皮质激素受体关系研究

The Relationship Between the Rabbit Glucocorticoid Receptor and Steroid induced Glaucoma

目的 :研究家兔糖皮质激素受体 (GR)与激素性青光眼 (SIG)的关系。方法 :实验前测定家兔外周血白细胞糖皮质激素受体 (GR)、血浆皮质醇 ,实验中隔日给家兔结膜下注射地塞米松 0 .5mg ,共 15次 30天 ,每周测量家兔眼压、房水流畅系数C值一次 ,分析GR、血浆皮质醇与眼压、C值的改变值间的关系。结果 :GR与眼压、C值的改变值间具有相关性 (P <0 .0 2 5、P <0 .0 1) ,血浆皮质醇与眼压、C值的改变值间无相关性 (P >0 .0 5、P >0 .0 5 )。结论

Objective:To study the correlation between the rabbit glucocorticoid receptor(GR)and steroid induced glaucoma(SIG).Methods:The GR binding in peripheral blood leukocytes and plasma cortisol was measured in 15 adult pigmented rabbits in the first day of the experiment,0.5mg dexamethasone was injected in the right eyes of each rabbit every 2 days,15 times for 30 days.The intraocular pressure(IOP)and aqueous outflow racility of the right eyes were measured every week.Analyse the relation between GR,plasma cortisol,IOP and aqueous outflow facility (C).Results:After the experiment the IOP increased by (0.67±0.49)kPa( P <0.01),C decreased by (0.08±0.11)( P <0.01).GR may closely be related with IOP and C( r =0.56, P <0.025; r =0.60, P <0.01).Plasma cortisol was independent of IOP and C( r =0.27, P >0.05; r =0.34, P >0.05).Conclusion:The level of GR has a positive correlation with the sensitivity of the eye tissue to glucocorticoid.