摘要
目的 探讨谷胱甘肽对抗结核药所致轻、中度肝损害的疗效。方法 抗结核药所致肝损害病人97例,分成2组,治疗组62例,不停抗结核药,加用谷胱甘肽0.6g,静脉滴注,qd×3wk。对照组35例,停用抗结核药,不用谷胱甘肽。2组均采用基础治疗(肌苷、维生素 B_1)。结果 2组总有效率分别为89%和66%,治疗前后血清天冬氨酸转氨酶、丙氨酸转氨酶、总胆红素的差值治疗组分别为:(-69±43)IU·L^(-1),(-116±17)IU·L^(-1),(-74±14)μmol·L^(-1);对照组为(-34±41)IU·L^(-1),(-40±14)IU·IL^(-1),(-41±11)μmol·L^(-1)。结论 谷胱甘肽对抗结核药所致的轻、中度肝损害有明显的治疗作用。
Objective To study ameliorating effects of glutahione in treating light or moderate liverinjury resulted from antitubercurlosis drugs.Methods Ninety-seven patients with such liver injury were divid-ed into two groups,treatment group and control group.Sixty-two patients of treatment group which still on an-titubercular regimen were given glutathione,0.6g,iv,gtt,qd×3wk.Thirty-five patients of control groupwhich stoppage of the regimen were not given glutathione treatment,2 groups were all given inositol and vita-min B_1.Results Both in group treatment and control,the total effective rates were 89% and 66% respec-tively.In treatment group,the difference of aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TB)was(-69±43)IU·L^(-1),(-116±17)IU·L^(-1),(-74±14)μmol·L^(-1);in control group,it was(-34±41)IU·L^(-1),(-40±14)IU·L^(-1),(-41±11)μmol·L^(-1),respectively.Conclusion Glutathione has marked ameliorating antituberculosis effects in treating light or moderate liver in-jury resulted from drugs.
