3,5-二氯苯甲酸的合成研究

Synthesis of 3,5-Dichloro-benzoic acid

研究了3,5-二氯苯甲酸的合成方法。首先,以邻氨基苯甲酸为原料制备2-氨基-3,5-二氯苯甲酸。通过分析影响该实验的因素,以质量为指标设计了正交实验方案,再用极差分析法处理实验数据。然后以3,5-二氯邻氨基苯甲酸为原料在高温下重氮化反应,制备3,5-二氯苯甲酸;用红外分光光度计、核磁共振仪对2种物质的结构进行了表征,用熔点仪初步估计产物纯度,再用高效液相色谱仪检测产物中纯物质的含量,从而得到了3,5-二氯邻氨基苯甲酸及3,5-二氯苯甲酸的最佳合成条件。

To study the synthesis methods of 3,5-dichloro-benzoic acid. To synthesize 2-amino 3,5-dichlorobenzene formic acid by using anthranilic acid as raw materials. Through the analysis of the factors of affecting the experi- ment, to design the orthogonal experiment scheme for quality of the index, process the experimental data by virtue of range analysising method. To synthesize 3,5-dichlorobenzene formic acid by using high temperature diazotization reaction of the 3,5-dichloro anthranilic acid as raw material. To characterize the structure of two kinds of material with infrared spectrophotometer and nuclear magnetic resonance instrument. By melting point apparatus,to estimate product purity has been preliminarily, and test the pure substance content in products by high performance liquid chroma- tograph,and get the best synthesis conditions of 3,5-dichloro-benzoic acid and 3,5-dichloro anthranili acid.