腹膜透析患者代谢综合征危险因素分析

An analysis of the risk factors for metabolic syndrome in patients undergoing peritoneal dialysis

目的探讨腹膜透析患者新发代谢综合征(MS)的危险因素。方法回顾性分析了腹膜透析时间超过24个月,并且稳定透析3个月时无MS的95例非糖尿病患者资料,对可能影响新发生MS的危险因素进行总结。以是否新发MS为因变量,纳入高尿酸(UA)血症、甘油三酯(TG)、高密度脂蛋白(HDL)、空腹血糖(Glu)和体重指数(BMI)5个变量引入方程进行多因素logistic回归分析。结果 95例患者新发MS组42例,无MS组53例。高UA血症(OR=5.076)、高TG(OR=3.134)、低HDL(OR=0.002)、高Glu(OR=3.163)和高BMI(OR=1.493)均与新发MS密切相关(P<0.05)。结论腹膜透析患者MS发病率较一般人群高;高UA血症、高TG、低HDL、高Glu和高BMI为新发MS的独立危险因素。

Objective To analyze the risk factors for new-onset metabolic syndrome（MS） in the patients undergoing peritoneal dialysis. Methods Data of 95 patients undergoing peritoneal dialysis were retrospectively analyzed, who underwent dialysis for more than 24 months and had a stable peritoneal dialysis for three months without MS and diabetes. Taking MS as the dependent variable, the multiple Logistic regression analysis was performed when the five variables of hyperuricemia （UA）, triglyceride（TG）, high-density lipoprotein （HDL）, fasting blood sugar （GLU） and body mass index（BMI） were put into equation. Results Of 95 patients, 42 cases occurred metabolic syndrome （group MS） and 53 cases had no MS（group NMS）. The high UA（OR=5.076）, high TG （OR=3. 134） ,low HDL（OR=0. 002）, high GLU（OR=3. 163）, and high BMI（OR=1. 493） were closely related to MS（P^0. 05）. Conclusion The incidence of MS is higher in the patients undergoing peritoneal dialysis, in whom the high UA, high TG, low HDL, high GLU, and high BMI are the independent risk factors for the new-onset metabolic syndrome.