运动员生物护照血液模块的研究进展

The Research Progress of Athlete Biological Passport-Blood Module

从早期的自体血液回输到异体血液回输,再到重组人促红细胞生成素(rhEPO)的问世,血液兴奋剂在体育运动中的使用经历了漫长的演变过程。与兴奋荆的直接检测相比,运动员生物护照具有不受使用物质或方法的限制,相对费用较少,比较方便等优势,它分为用于类固醇检测的类固醇模块、用于肽类兴奋剂的内分泌模块和用于血液兴奋荆的血液模块。从以下几方面综述运动员生物护照血液模块方面的研究进展:1)多参数间接检测;2)异质性因素和混淆性因素的影响;3)纵向监测;4)血液兴奋剂滥用度问题以及采样的分析前变异和分析变异问题。

With a long history of evolution, blood doping changes from autologous blood transfusion to homologous blood transfusion then to rhEPO. Compared with direct detection methods, athlete biological passport is independent of the substances or methods, economic, convenient and time-saving. The athlete biological passport can be classified as three modules： the ＂steroid module＂ designed for steroid detection, the ＂endocrine module＂ for peptide doping detection, and the ＂ blood module＂ for blood doping detection. The paper elaborates the research progress of athlete biological passport from the following aspects, that is, multi- parameter detection, the effect of heterogeneous and confounding factors, longitudinal detection, the prevalence of doping, pre- analysis variance and analytical variance, etc.