摘要
应用PCR 扩增方法检测203 例NIDDM 患者和165 例正常对照者血管紧张素(ACE)基因的16 内含子中287bp 片段缺失/插入多态性。结果显示，糖尿病肾病患者组ACE 基因缺失纯合型(DD)频率明显高于非肾病组和正常对照组，P<0.001；DD 缺失纯合型患者肾病进展速度明显快于缺失/插入(DI)杂合型及插入/插入(II)纯合型糖尿病患者，P<0.01。表明ACE 基因缺失纯合型是糖尿病肾病的独立危险因素之一，并可作为NIDDM 肾病发生发展的有效预测指标。
To investigate the association of deletion/insertion polymorphism the onset and of angiotensin converting enzyme ACE gene with diabetic nephropathy in NIDDM A case-control study was carried out in 203 NIDDM patients 109 with DN 94 without DN and 216 control subjects The 287bp deletion/insertion polymorphism of ACE gene was deleted by polymerase chain reaction PCR DD genotype frequencies were significantly increased in DN group than that in the group without DN and controls DN v.s control P<0.001 DN v.s NDN P<0.01 respectivity conclusion the DD genotype of ACE gene might be an independent risk factor for the onset and procession of diabetic nephropathy in chinese Han's NIDDM patients
出处
《基础医学与临床》
CSCD
2000年第5期27-29,共3页
Basic and Clinical Medicine
基金
国家自然科学基金!39670693 39870687
关键词
血管紧张素转换酶
基因多态性
糖尿病肾病
Angiotensin converting enzyme
gene polymorphism
diabetic nephropathy
