Ezrin、c-Met和CD44v6在胃癌中的表达及其相关性

Expression and relationship of Ezrin、c-Met and CD44v6 in gastric cancer

目的探讨Ezrin、c-Met和CD44v6在胃癌中的表达情况,分析其相关性以及与胃癌生物学特性的关系。方法采用免疫组织化学方法检测Ezrin、c-Met和CD44v6在130例胃癌组织中的表达情况。结果 130例胃癌组织中Ezrin阳性表达率为61.0%;c-Met阳性表达率为58.0%;CD44v6阳性表达率为53.0%。Ezrin和CD44v6的表达情况与临床分期、淋巴结转移以及TNM分期有关(P<0.05);c-Met的表达与浸润深度、淋巴结转移以及TNM分期有关(P<0.05)。胃癌组织中Ezrin分别与c-Met、CD44v6表达水平呈正相关,且c-Met与CD44v6表达呈正相关(P<0.05)。结论 Ezrin和肿瘤转移相关分子c-Met、CD44v6可能在胃癌浸润转移中起着协同作用,联合检测其表达情况可为胃癌侵袭转移的监测以及治疗和判断其预后提供新的依据。

Objective To investigate the expression, relationship and tumor biology characters between Ezrin, c-Met and CD44v6 in gastric cancer. Methods The expression of Ezrin, c- Met and CD44v6 of gastric cancer samples from 130 patients was analyzed by immunohisto- chemistry. Results Ezrin was expressed in 61.0% of 130 gastric cancer samples. High levels expression of c-Met and CD44v6 were found in 58.0% and 53.0% of tumors samples respec- tively. Ezrin expression exhibited a positive correlation with c-Met and CD44v6 expression, and CD44v6 expression was positively correlated with the expression of c-Met （P 〈 0. 05 ）. Positive expression of Ezrin and CD44v6 were significantly associated with tumor stage, lymph node me- tastasis and TNM stage （P 〈 0. 05 ）. C-Met expression was correlated with invasion depth, lymph node metastasis and TNM stage. Conclusion Ezrin,c-Met and CD44v6 are tumor me- tastasis-associated markers that have synergistic effect in gastric cancer infiltration and metasta- sis. Combined analysis of these molecules may offer new useful information on invasion, metas- tasis, speculated prognosis and therapy.