蛙皮素受体亚型-3在肺疾病中的研究进展

Research Progress of Bombesin Receptor Subtype-3 in Lung Diseases

蛙皮素受体亚型-3(BRS-3)属G蛋白偶联受体,至今未发现天然配体。BRS-3具有广泛的生物学作用,可调控神经内分泌功能、能量代谢及细胞生长增殖。在啮齿类动物及哺乳动物体内都有分布,大多数组织表达水平很低(包括正常肺组织),但在某些肺部疾病及胎肺中表达增加。就BRS-3受体特点、激活后信号转导机制及其与肺肿瘤、肺发育、慢性炎症性肺病的联系作一综述。

Bombesin Receptor Subtype--3 （BRS--3） is a G Protein--coupled receptor and the natural ligand for BRS--3 remains unknown to date. BRS--3 has been shown to elicit extensive biological effects, including regulations of neuroendocrine, energy metabolism and cell proliferation. BRS--3 is found in rodents and mammals. Very low levels of expression are detected in majority of normal tissues including lung tissue, but high levels in some pulmonary diseases and fetal lung. Here we review the literature pertaining to the characteristics of BRS--3, signal transduction mechanisms when activated, and connections with lung cancer, lung development and chronic inflammatory lung diseases.