丙泊酚对肺动脉高压患者肺循环的影响

Effects of Propofol on Pulmaonary Circulation in Patients with Pulmonary Hypertension

肺动脉高压是一类预后很差的综合征,尽管药物治疗有所发展,但至今仍没有很好的治疗方法。手术及麻醉过程中的很多因素可引起肺血管阻力增高,如缺氧、手术刺激、炎性介质等,对于手术过程中有肺动脉高压的患者选择合适的麻醉药维持循环稳定,防止肺循环阻力进一步增高至关重要。丙泊酚是一种常用的静脉麻醉药,现综述丙泊酚对肺动脉高压手术患者肺循环的影响,探讨丙泊酚用于肺动脉高压患者麻醉中的益处。

Pulmonary artetial hypertension（PAH） is a kind of syndrome with poor progonosis,although novel drugs have been developed,the chance of survival remains poor.Many factors can cause pulmonary artery pressure to increase,such as hypoxia,operation stimulation,mediators of inflammation,and so on.It is very important to maintain circulation stabilization and prevent further increase of pulmonary artery pressure by choosing right anesthetics.Propofol,an intravenous anesthetic,is most common in clinical use.Here is to summarize the effects of propofol on pulmonary circulation in patients with PAH under operation to discuss the benefits of propofol in such cases.