美托洛尔用于急性心肌梗死早期的临床疗效分析

Analysis on the Clinical Efficacy of Metoprolol for the Treatment of Early Acute Myocardial Infarction

目的探讨美托洛尔用于急性心肌梗死早期的临床疗效。方法选取2010年3月至2011年11月因急性心肌梗死而在武警辽宁省总队医院进行治疗的患者98例,随机分为试验组(51例)和对照组(47例),对照组患者心肌梗死早期给予卡托普利2.5～20 mg,每日2次,口服;试验组在对照组治疗的基础上加入美托洛尔12.5～100 mg,每日2次,口服。两组患者的其他治疗方法相同,统计分析两组治疗方法的临床效果。结果试验组患者的生存率及左心室重构延缓的程度明显高于对照组,比较差异有统计学意义(均P<0.05)。结论将美托洛尔应用于心肌梗死早期患者能够显著降低患者病死率,同时能延缓心室重构,临床意义重大。

Objective To discuss the effect of metoprolol for the treatment of early acute myocardial infarction.Methods From March,2010 to November 2011,98 patients in Liaoning Armed Police Corps Hospital with early acute myocardial infarction were randomly divided into trial group（51 cases） and control group（47 cases）.The trial group was given metoprolol（12.5-100mg） combined with captopril,2 times per day taken orally;and the control group was given captopril（2.5-20 mg）,2 times per day taken orally.The other methods were the same in the two groups.After the treatment,the curative effects were compared statistically between the two groups.Results The survival rate and left ventricular remodeling delaying of the trial group was apparently higher than the control group With statistically significant difference（P0.05）.Conclusion Metoprolol as the treatment of the patients with early acute myocardial infarction can significantly reduce the mortality and delay the ventricular remodeling,which is of great clinical significance.