非糖尿病腹膜透析患者糖化血红蛋白水平与颈动脉内中膜厚度的相关性

Correlation between glycosylated hemoglobin and carotid intima- media thickness in nondiabetic peritoneal dialysis patients

目的探讨非糖尿病腹膜透析患者糖化血红蛋白（HbAlc）水平与颈动脉内中膜厚度（CIMT）的相关性，明确HbAlc是否为颈动脉硬化的预测因子。方法选择非糖尿病腹膜透析的成年患者42例[平均年龄（48．2±12．3）岁，男性21例]，超声检测CIMT，按CIMT厚度分为两组：CIMT正常组（CIMT〈0．9ITIITI）和CIMT增厚组（CIMT≥0．9mm）。使用Spearman秩相关和多重线性回归分析CIMT的影响因素。结果非糖尿病腹膜透析患者CIMT与年龄、餐后2h血糖、LDL-C、TG、TC、HbAlc呈正相关【r=0．355、0．373、0．416、0．345、0．351、0．456，均P〈0．05），而HbAlc对CIMT的影响最大（β=0．459）。结论在非糖尿病腹膜透析患者中，HbAlc水平与CIMT正相关，HbAlc可能是颈动脉硬化的预测因子。

Objective To investigate the correlation between glycosylated hemoglobin （HbAlc） and carotid intimamedia thickness （CIMT） in non- diabetic peritoneal dialysis patients. Methods Forty-two non-diabetic peritoneal dialysis adult patients were enrolled in this study [mean age was （48.2± 12.3） years, 50% was male]. CIMT was determined by carotid ultrasound. Patients were divided into two groups according to CIMT： CIMT normal group （CIMT 〈 0.9 mm） and CIMT thickening group （CIMT≥0.9 mm）. HbAlc, 2-hour postprandial blood glucose （2hPBG） and other factors of the patients were analyzed with Spearman rank correlation and multiple linear regression. Results CIMT was correlated with age, 2hPBG, LDL-C, TG, TC, HbAlc in non-diabetic peritoneal dialysis patients （r = 0.355, 0.373, 0.416, 0.345, 0.351, 0.456, all P 〈 0.05）. Multiple linear regression showed that HbAlc was the most powerful influence factor of CIMT（β = 0.459）. Conclusion HbAlc level is positively correlated with CIMT and may be a predictor of carotid atherosclerosis in non- diabetic peritoneal dialysis patients.