摘要
目的探讨非糖尿病腹膜透析患者糖化血红蛋白(HbAlc)水平与颈动脉内中膜厚度(CIMT)的相关性,明确HbAlc是否为颈动脉硬化的预测因子。方法选择非糖尿病腹膜透析的成年患者42例[平均年龄(48.2±12.3)岁,男性21例],超声检测CIMT,按CIMT厚度分为两组:CIMT正常组(CIMT〈0.9ITIITI)和CIMT增厚组(CIMT≥0.9mm)。使用Spearman秩相关和多重线性回归分析CIMT的影响因素。结果非糖尿病腹膜透析患者CIMT与年龄、餐后2h血糖、LDL-C、TG、TC、HbAlc呈正相关【r=0.355、0.373、0.416、0.345、0.351、0.456,均P〈0.05),而HbAlc对CIMT的影响最大(β=0.459)。结论在非糖尿病腹膜透析患者中,HbAlc水平与CIMT正相关,HbAlc可能是颈动脉硬化的预测因子。
Objective To investigate the correlation between glycosylated hemoglobin (HbAlc) and carotid intimamedia thickness (CIMT) in non- diabetic peritoneal dialysis patients. Methods Forty-two non-diabetic peritoneal dialysis adult patients were enrolled in this study [mean age was (48.2± 12.3) years, 50% was male]. CIMT was determined by carotid ultrasound. Patients were divided into two groups according to CIMT: CIMT normal group (CIMT 〈 0.9 mm) and CIMT thickening group (CIMT≥0.9 mm). HbAlc, 2-hour postprandial blood glucose (2hPBG) and other factors of the patients were analyzed with Spearman rank correlation and multiple linear regression. Results CIMT was correlated with age, 2hPBG, LDL-C, TG, TC, HbAlc in non-diabetic peritoneal dialysis patients (r = 0.355, 0.373, 0.416, 0.345, 0.351, 0.456, all P 〈 0.05). Multiple linear regression showed that HbAlc was the most powerful influence factor of CIMT(β = 0.459). Conclusion HbAlc level is positively correlated with CIMT and may be a predictor of carotid atherosclerosis in non- diabetic peritoneal dialysis patients.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
2013年第3期169-172,共4页
Chinese Journal of Nephrology
关键词
糖化血红蛋白
颈动脉狭窄
腹膜透析
非糖尿病
Glycosylated hemoglobin
Carotid stenosis
Peritoneal dialysis
Non-diabetic