姜黄素对大鼠胸主动脉瘤JNK信号通路的影响

Effect of curcumin on JNK pathway in rat thoracic aortic aneurysm

目的：探讨姜黄素对大鼠胸主动脉瘤形成过程中JNK信号的影响。方法：成年雄性Wistar大鼠随机分为对照组、动脉瘤组和姜黄素治疗组。采用氯化钙（CaCl2）诱导法制备胸主动脉瘤模型,术后4周取材。H-E染色及地衣红染色观察胸主动脉组织学改变;免疫组织化学检测动脉瘤壁p-JNK和p-c-Jun的表达。结果：姜黄素可明显抑制胸主动脉的扩张。与对照组比较,动脉瘤组p-JNK和p-c-Jun表达水平明显升高,而姜黄素能有效抑制动脉瘤中JNK和cJun的磷酸化。结论：姜黄素抑制胸主动脉瘤的发展有可能与其抑制JNK信号相关。

Objective： To investigate the effect of curcumin on the JNK signal pathway during rat thoracic aortic aneurysm for Results： Curcumin can inhibit the expansion of the thoracic aorta. Compared with the control group, the expression of p-JNK and p-c-Jun was higher in the aneurysm group, and curcumin effectively inhibited the phosphorylation of JNK and c-Jun. Conclusion： Curcumin inhibited the development of thoracic aortic aneurysms, which may be related to the inhibition of JNK signaling.