摘要
1,3,4-噁二唑类很多领域都有广泛的应用。目前合成对称的2,5-二取代1,3,4-噁二唑的主要途径是在脱水剂存在的条件下,使酰氯和酰肼反应制备得对称的二酰胺脱水环合。以对羟基苯甲酸甲酯和对氰基苯酚为原料合成了2,5-二(对烷氧基苯基)-1,3,4-噁二唑类化合物,实验过程简单,条件温和,收率良好。实验中采用乙醇做溶剂,在滴加乙酰氯的情况下生成反应所需的氯化氢气体。这种方法避免了直接通入氯化氢带来的麻烦。产物的结构由1H NMR和13C NMR确定。
1,3,4-Oxadiazoles has been widely used in various fields. The synthesis of symmetrically 2,5- disubstituted 1,3,4-oxadiazoles from diacylhydrazines prepared from acid chloride and hydrazine can be performed by using cyclodehydrating agents. In this paper, 2,5-bis （4-alkoxy-phenyl） -1,3,4-oxadiazoles were synthesized from methy 4-hydroxybenzoate and 4-cyanophenol. The process of experiments was simple, the conditions were mild and the yields were quite good. Hydrogen chloride gases needed in the experiment were prepared from dropping acetylchloride into ethanol which was also the solvent of the reaction. This method can avoid the trouble caused by flowing hydrogen chloride gases directly. The struc- tures were characterized by ^1 H NMR and ^13C NMR.
出处
《化学工业与工程》
CAS
2013年第2期36-39,共4页
Chemical Industry and Engineering
关键词
1
3
4-噁二唑
关环
合成
1,3,4-oxadiazoles
ring-closing
synthesis
