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间充质干细胞治疗急性肺损伤的研究进展 被引量：2

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摘要 急性肺损伤／急性呼吸窘迫综合征（ALI／／ARDS）是指肺内、外严重疾病导致的以肺毛细血管弥漫性损伤、通透性增强为基础，以肺水肿、透明膜形成和肺不张为主要病理变化，以进行性呼吸窘迫和难治性低氧血症为临床特征的急性呼吸衰竭综合征，目前尚无有效的治疗方法。间充质干细胞（mesenchymalstemcells，MSCs）具有多向分化潜能、能分泌多种细胞因子调节肺内皮和上皮通透性，增加肺泡液体清除率，具有抗炎和抗菌等多种生物学特性。近年来MSCs已被广泛用于治疗ALI的实验研究，现将MSCs治疗ALI的实验进展及机制研究作一综述。
作者 金海玉 吴晓梅
机构地区 哈尔滨医科大学附属第二医院呼吸内科
出处 《中国呼吸与危重监护杂志》 CAS 2013年第2期207-211,共5页 Chinese Journal of Respiratory and Critical Care Medicine
关键词 间充质干细胞 急性肺损伤 干细胞治疗 急性呼吸窘迫综合征 急性呼吸衰竭综合征 难治性低氧血症 肺泡液体清除率 多向分化潜能
分类号 R563.8 [医药卫生—呼吸系统]
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参考文献40

  • 1Friedenstein AJ, Petrakova KV, Kurolesova AI, et al. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation, 1968,6:230-247.
  • 2Takashima Y, Era T, Nakao K, et al. Neuroepithelial cells supply an initial transient wave of MSC differentiation. Cell, 2007,129:1377- 1388.
  • 3Bi Y, Ehirchiou D, Kilts TM, et al. Identification of tendon stem/ progenitor cells and the role of the extracellular matrix in their niche. Nat Med,2007 ,13 :1219-1227.
  • 4Crisan M, Yap S, Casteilla L, et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell, 2008,3:301-313.
  • 5Igura K, Zhang X, Takahashi K, et al. Isolation and characterizationof mesenchymal progenitor cells from chorionic villi of human placenta. Cytotherapy,2004,6 : 543 -553.
  • 6Xu Y, Malladi P, Wagner DR, et al. Adipose-derived mesenchymal cells as a potential cell source for skeletal regeneration. Curr Opin Mol Ther,2005,7 : 300 -305.
  • 7Mansilla E, Matin GH, Sturla F, et al. Human mesenchymal stem cells are tolerized by mice and improve skin and spinal cord injuries. Transplant Proc,2005,37:292-294.
  • 8Ries C, Egea V, Karow M, et al. MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem ceils : differential regulationby inflammatory cytokines. Blood, 2007, 109:4055-4063.
  • 9Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood,2005,105 : 1815-1822.
  • 10Corcione A, Benvenuto F, Ferretti E, et al. Human mesenehymal stem cells modulate B-cell functions. Blood ,2006,107:367-372.

二级参考文献22

  • 1冯善伟,姚晓黎,李中,柳太云,黄文,张成.BrdU体外标记大鼠骨髓间充质干细胞的研究[J].第一军医大学学报,2005,25(2):184-186.
  • 2XIE,Hai-yang（谢海洋）,HUANG,Dong-sheng（黄东胜）,JIA,Chang-ku（贾长库）,ZHENG,Shu-sen（郑树森）.Infusion of nonmyeloablative bone marrow alleviates acute rejection reaction in liver allotransplantation[J].Journal of Zhejiang University-Science B(Biomedicine & Biotechnology),2005,6(12):1188-1194. 被引量：2
  • 3Crapo JD, Barry BE, Foscue HA, et al. Structural and biochemical changes in rat lungs occurring during exposure to lethal and adaptive doses of oxygen. Am Rev Respir Dis, 1980,122 : 123-143.
  • 4Collard K J, Godeck S, Holley JE, et al. Pulmonary antioxidant concentrations and oxidatite damage in ventilated premature babies. Arch Dis Child Fetal Neonatal Ed,2004,89 :F412-F416.
  • 5Idell S. Coagulation, fibrinolysis, and fibrin deposition in acute lung injury. Crit Care Med,2003,31 (4 Suppl) :S213-220.
  • 6Stem D, Yan SD, Yan SF, et al. Receptor for advanced glyeation endproduets: a muhiligand receptor magnifying cell stress in diverse pathologic settings. Adv Drag Deliv Rev, 2002,54:1615- 1625.
  • 7Su X,Looney MR,Gupta N,et al. Receptor for advanced glyeation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. Am J Physiol Lung Cell Mol Physio1,2009,297 : L1-L5.
  • 8Creagh-Brown BC, Quinlan G J, Evans TW,et al. The RAGE axis in systemic inflammation, acute lung injury and myocardial dysfunction: an important therapeutic target? Intensive Care Med, 2010,36 : 1644-1656.
  • 9Matthay MA, Thompson BT, Read E J, et al. Therapeutic potential of mesenchymal stem cells for severe acute lung injury. Chest, 2010,138:965-972.
  • 10Ramasamy R,Vannucci SJ,Yan SS,et al. Advanced glycation endproducts and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. Glycobiology, 2005, 15 : 16R-28R.

共引文献13

同被引文献35

  • 1Tuan RS, Boland G, Tuli R. Adult mesenchymal stem cells and cell-based tissue engineering [ J ]. Arthritis Res Ther,2003,5 ( 1 ) : 32 - 45.
  • 2Conger PA, Minguell JJ. Phenotypical and Functional Properties of Human Bone Marrow Mesenchymal Progenitor Ceils [ J ]. J Cell Physiol, 1999,181 ( 1 ) :67 - 73.
  • 3Definition Task Force ARDS, Ranieri VM, Rubenfeld GD, et al. Acute respiratory distress syndrome: the Berlin definition [ J ]. JAMA 2012, 307:2526 - 2533.
  • 4Matthay MA, Ware LB, Zimmerman GA. The acute respiratory distress syndrome[ J]. J Clin Invest, 2012, 122:2731 - 2740.
  • 5Zhao YF,Xiong W, Wu XL. Mesenchymal stem cell-based devel- opmental endothelial locus-1 gene therapy for acute lung injury in- duced by lipopolysaccharide in mice [ J ]. Mol Med Rep, 2014,9 (5) :1583 -9.
  • 6Jianjun Li, Dong Li, Xiaomei Liu, et al. Human umbilical cord mesenchymal stem ceils reduce systemic inflammation and attenu- ate LPS-induced acute lung injury in rats [ J ]. Journal of Inflam- mation,2012, 9( 1 ) :33.
  • 7Lee JW, Krasnodembskaya A, McKenna DH, et al. Therapeutic effects of human mesenchymal stem ceils in ex vivo human lungs injured with live bacteria[J]. Am J Respir Crit Care Med, 2013, 187(7) :751 -760.
  • 8Kathleen D Liu et al. Design and implementation of the START (Stem cells for ARDS Treatment) trial, a phase 1/2 trial of hu- man mesenchymal stem/stromal cells for the treatment of moder- ate-severe acute respiratory distress syndrome [ J ]. Annals of In- tensive Care,2014, 4:22.
  • 9Marianne Fitzgerald, Daniel F McAuley, Michael Matthay. Is there a need for emerging drugs for the acute respiratory distress syn- drome? Expert Opin[ J 1. Emerging Drugs, 2014,19 ( 3 ) : 323 - 328.
  • 10Lee JW, Gupta N, Serikov V, et al. Potential application of mes- enchy-mal stem ceils in acute lung injury [ J ]. Expert Opin Biol Ther, 2009, 9(10) : 1259 -1270.

引证文献2

二级引证文献3

中国呼吸与危重监护杂志
2013年 第2期

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