摘要
目的探讨胃旁路术对SD大鼠体质量减轻的影响。方法将35只12周龄的雄性SD大鼠随机分为手术组（O）15只、假手术饮食控制组（C）10只及假手术空白对照组（B）10只，0组行胃旁路术，c组饲料量与O组相同，B组给予足量饲料，观察各组大鼠术前及术后每日体质量变化及每周进食量。结果O组大鼠死亡7只，存活率53-3％；0组大鼠在术后第1周内体质量下降幅度最大，其后体质量出现反弹但较其他各组上升缓慢。结论通过SD大鼠建立胃旁路术模型是可行的，胃旁路术可有效控制SD大鼠体质量。
Objective To establish the model of gastric bypass surgery （RYGB） in SD rats, and to study the effect of gastric bypass surgery on weight loss. Methods Thirty five male SD rats were randomly divided into three groups￡°gastric bypass surgery was performed in 15 male rats as the study group （O group）, sham operation was performed in 10 male rats which were given diet control after operation as the study control group （C group）, and laparotomy was performed in 10 male rats which were given normal diet control after operation as the blank control group （B group）. Body weight and food intake were recorded before and after surgery. Results The number of death rats was 7 in the study group, and the survival rate is 53.3%; the maximum weight loss was happened in the first week after surgery, thereafter weight rebounded slower than group B and C （P〈0.05）. Conclusions It is feasible to established gastric bypass surgery model in rats. RYGB can control weight of rat effectively.
出处
《实验动物与比较医学》
CAS
2013年第1期44-46,共3页
Laboratory Animal and Comparative Medicine
基金
教育部高等学校博士点专项科研基金资助课题（20103321120001）
浙江省自然科学基金（Y2110335）
浙江省卫生厅医药卫生一般研究计划项目（2011KYA111）
关键词
动物模型
胃旁路术
减重
Animal model
Gastric bypass surgery
Weight loss
