摘要
目的评价细胞周期素依赖性激酶5调节亚单位相关蛋白1类似物1(CDKAL1)基因rs7756992位点多态性与2型糖尿病(T2DM)的关系。方法检索国内外有关CDKAL1基因rs7756992与T2DM关系的随机对照研究文献,提取相关数据并应用RevMan5.0软件进行Meta分析。结果共纳入11篇文献,包括T2DM组32604例,对照组23939例。Meta分析结果显示,等位基因及隐性遗传模式下合并OR(95%CI)分别为1.18(1.13,1.23)和1.34(1.25,1.44)。亚组分析结果显示,CDKAL1基因rs775699位点多态性与亚洲和欧洲人群T2DM发病均存在关联。结论在在等位基因比较及隐性遗传模式下,CDKAL1基因rs7756992位点G等位基因突变均为亚洲和欧洲人群T2DM的危险因素。
Objective To evaluate the association of cyelin-dependent kinase 5 regulatory subunit-associated pro- tein l-like 1 (CDKAL1) gene rs7756992 polymorphism and type 2 diabetes mellitus (T2DM). Methods The case-control studies of CDKAL1 rs7756992 polymorphism and T2DM were collected and meta-analysis was performed by RevMan 5.0 software. Results A total of 11 documents concerning 32 604 diabetics and 23 939 controls were included in this study. The summary ORs(with 95% CI)under allele contrast and recessive model were 1.18 (1.13, 1.23) and 1.34 (1.25, 1.44), respectively. Subgroup analysis showed the correlation between the CDKAL1 gene rs7756992 polymorphism and incidence of T2DM in European and Asian populations. Conclusion In Asian and European populations, the allele G is the risk factor to T2DM under the two heredity models.
出处
《天津医药》
CAS
北大核心
2013年第3期244-251,共8页
Tianjin Medical Journal
基金
天津市科技攻关项目(项目编号:033113211)