CD133+细胞含量对自体骨髓干细胞移植治疗肝硬化疗效的影响

The effects of CD133+ cell on the efficacy of autologous bone marrow stem cell transplantation in patients with cirrhosis

目的研究分离骨髓干细胞后CD133+细胞含量对自体骨髓干细胞移植治疗肝硬化疗效的影响。方法回顾性分析自体骨髓干细胞移植治疗肝硬化病例39例,其中CD133+细胞含量不足2%的22例,CD133+细胞含量超过2%(含2%)的17例。分析上述病例术后2～4周的实验室检测指标。结果在CD133+细胞含量不足2%的病例中,患者术后的血清总蛋白、碱性磷酸酶和白蛋白均较术前明显增高(P<0.05)。在CD133+细胞含量超过2%的病例中,患者术后的血清总蛋白和白蛋白较术前明显增高(P<0.05)。结论自体骨髓干细胞移植可以有效的提升肝硬化患者血清总蛋白和白蛋白水平,本组病例中CD133+细胞含量的不同并未明显影响术后患者血清总蛋白、白蛋白的恢复水平。自体骨髓干细胞移植可能影响胆汁的排泌。

Objective To investigate the effects of CD133＋ cell on the efficacy of autologous bone mar- row stem cell transplantation in patients with cirrhosis. Methods Thirty nine patients with cirrhosis treated with autologous bone marrow stem cell transplantation were analyzed retrospectively. There were 22 cases with CD133＋ cell less than 2% and 17 cases with CD133＋ more than 2% （including 2%）. The results of labora- tory test of the patients during 2-4 weeks after the transplantation were collected and analyzed. Results After transplantation, the level of serum total protein, albumin and AKP of patients with CD133＋ less than 2% was higher than that of pretransplantation （P 〈 0.05）, and the level of serum total protein and albumin of patients with CD133＋ more than 2% was also higher than that of pretransplantation （P 〈 0.05）. Conclusions Autolo- gous bone marrow stem cell transplantation could improve the level of serum total protein and albumin of pa- tients with cirrhosis, and CD133＋ cell count did not affect the improvement of serum total protein and albumin after transplantation. Autologous bone marrow stem cell transplantation may have effect on the bile drainage.