恶性疟原虫PfEMP-1的研究进展

Research progress in PfEMP-1 of Plasmodium falciparum

目的恶性疟原虫红细胞表面蛋白-1(PfEMP-1)是由var基因家族编码的一种蛋白质,它是疟原虫在宿主体内存活的重要蛋白。不但参与疟原虫的抗原变异,调节人的免疫应答,而且还是重要的粘附分子。本文对PfEMP-1的基础结构特征及其与临床的病理联系,及以其为基础的抗疟疫苗研发方面的研究进展作一综述。

PfEMP-1 is encoded by members of Pgasmodium falciparurn （P. falciparurn） var gene family. As an im- portant protein of P. falciparurn which live in the host （mosquito and human）, it not only involves in the antigen variation and regulation of immune response, but also refers as an important cytoadherence molecule. In this article, PfEMP-1 is reviewed from the basic structure characteristics to the research and clinical application and promotion, and further explains would be given to the theoretical evidence for the feasibility of malaria vaccine development.