中药干预对创伤性应激障碍大鼠海马区移植间充质干细胞的保护作用

Protective effects of traditional Chinese medicine on mesenchymal stem cells transplanted into the hippocampus of rats with post-traumatic stress disorder

背景:骨髓间充质干细胞移植修复损伤海马具有较高的研究潜力,但是目前移植后干细胞的成活率较低这一问题尚未得到有效解决。目的:综述中药干预对创伤性应激障碍大鼠海马区移植间充质干细胞的保护作用。方法:应用计算机检索2000年1月至2012年1月PubMed数据库相关文章,检索词为"mesenchymal stem cells,transplantation,survival,post-traumatic stress disorder(PTSD),hippocampus",并限定文章语言种类为English,同时检索2000年1月至2012年1月CNKI数据库相关文章,检索词为"间充质干细胞,移植,存活率,创伤后应激障碍,海马",并限定文章语言种类为中文;共检索文献109篇。最终纳入符合标准的文献23篇。结果与结论:创伤后应激障碍作为一种由生物、心理、社会等多种因素作用的复杂疾病,治疗是亟待解决的问题,中医药在此领域具有独特的优势。创伤后应激障碍所造成的海马损伤可以通过骨髓间充质干细胞移植进行修复,运用调肝方药逍遥散干预,预期可有效提高移植干细胞的存活率。

BACKGROUND： Transplantation of bone marrow mesenchymal stem cells shows great potential in repair of hippocampal injury. However, low survival rate of transplanted stem cells remains unsolved.OBJECTIVE： To summarize the protective effects of traditional Chinese medicine on bone marrow mesenchymal stem cells transplanted in the hippocampus of rats with post-traumatic stress disorder.METHODS： The databases of Pubmed, and CNKI were retrieved for papers published from January 2000 to January 2012 with key words “mesenchymal stem cells, transplantation, survival and post-traumatic stress disorder （PTSD）, hippocampus” in English and Chinese. A total of 109 papers were retrieved. Among them, 23 papers were included in the final analysis.RESULTS AND CONCLUSION： Post-traumatic stress disorder is a complex disease influenced by biological, psychological, social and other factors and remains unsolved in treatment. Traditional Chinese medicine exhibits a unique advantage in this research field. Hippocampal damage caused by post-traumatic stress disorder can be repaired by transplantation of bone marrow mesenchymal stem cells. Bone marrow mesenchymal stem cell transplantation combined with intervention of Xiaoyaosan, a traditional Chinese medicine, is expected to increase the survival rate of transplanted stem cells.