干细胞移植治疗糖尿病肾病

Research progress in stem cell transplantation for treatment of diabetic nephropathy

背景:糖尿病肾病所致的终末期肾病已成为慢性肾功能衰竭的主要原因,传统的血液透析和肾脏移植已无法满足临床治疗的需求,以干细胞为基础的再生医学研究有可能为糖尿病肾病的治疗带来新的希望。目的:综合分析不同来源干细胞治疗糖尿病肾病的机制及临床研究进展。方法:应用计算机检索CNKI和PubMed数据库中2006年1月至2011年8月关于干细胞治疗糖尿病肾病的文章,在标题和摘要中以"胚胎干细胞;骨髓间充质干细胞;诱导性多能干细胞;糖尿病肾病"或Embryonic stem cells;Bone marrow mesenchymal stem cells;induced poluripotent stem cells;induced multipotent stem cells;diabetic nephropathy"为检索词进行检索。最终选择26篇文章进行综述。结果与结论:胚胎干细胞、骨髓间充质干细胞、诱导性多能干细胞均具有向肾脏组织细胞分化的潜能,大量研究表明干细胞移植对肾脏损伤和修复具有积极的作用。通过对干细胞相关特性的描述和相关机制的研究,干细胞移植有可能为糖尿病肾病提供一种新型的治疗方案。

BACKGROUND： Diabetic nephropathy-caused end-stage renal disease has become the main reason of chronic renal failure. Traditional hemodialysis and kidney transplantation cannot meet clinical needs. Regenerative medicine research based on stem cells brings new hope for treatment of diabetic nephropathy.OBJECTIVE： To comprehensively analyze the mechanism underlying different sources of stem cells for treatment of diabetic nephropathy and the clinical implications.METHODS： Papers addressing stem cells for the treatment of diabetic nephropathy were retrieved by computer in CNKI database and PubMed database from January 2006 to August 2011 with the key words ＂embryonic stem cells, bone marrow mesenchymal stem cells, induced pluripotent stem cells, diabetic nephropathy＂ in Chinese and English. Papers published recently or in journals with high impact factor were selected. A total of 26 papers were included for review. RESULTS AND CONCLUSION： Embryonic stem cells, bone marrow mesenchymal stem cells, induced pluripotent stem cells have the potential to differentiate into renal histiocyte. A large numbers of experimental studies have shown that stem cells transplantation has a positive effect on recovery of injured kidney. Stem cells transplantation can provide a novel therapy for diabetic nephropathy.